Prkcb protein kinase C, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkcbprovided by RGD
Official Full Name: protein kinase C, betaprovided by RGD
Primary source: RGD:3396
See related: EnsemblRapid:ENSRNOG00000012061 AllianceGenome:RGD:3396
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pkcb; Prkcb1
Summary: Predicted to enable several functions, including nuclear androgen receptor binding activity; nuclear receptor coactivator activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of insulin receptor signaling pathway; positive regulation of odontogenesis of dentin-containing tooth; and response to vitamin D. Located in brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 562.1), Spleen (RPKM 510.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (186263397..186594743)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (176832173..177163539)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (192233569..192575339)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway.
Title: LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway.
The Mfn1-betaIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage.
Title: The Mfn1-βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage.
Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCbeta Ser(660) phosphorylation and intracellular calcium.
Title: Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCβ Ser(660) phosphorylation and intracellular calcium.
Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCbeta/Mitochondrial Oxidant Signaling.
Title: Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCβ/Mitochondrial Oxidant Signaling.
FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC beta2 pathway.
Title: FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC β2 pathway.
data suggest that TRB3 mediates AGE-induced oxidative injury in beta-cells through the PKCbeta2 pathway.
Title: TRB3 mediates advanced glycation end product-induced apoptosis of pancreatic β-cells through the protein kinase C β pathway.
The authors took a proteomics approach using a PKCB knockout mast cell model and found that the key mast cell secretory protein VAMP8 becomes phosphorylated by PKC at multiple residues in the SNARE domain.
Title: Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.
Our results provide compelling evidence that glucose-induced PKCalpha/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction
Title: Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose.
reduced GLP-1R expression in spontaneously hypertensive rat renal arteries most likely mediated through PKCbeta upregulation
Title: Protein kinase Cβ mediates downregulated expression of glucagon-like peptide-1 receptor in hypertensive rat renal arteries.
PRKCBII and PRKCD-dependent inactivation of p38 regulates cardiac fibroblast proliferation and collagen deposition in response to angiotensin II.
Title: PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE108217 (e-PCR)
- UniSTS:247691

AI044240 (e-PCR)
- UniSTS:247957

RH94487 (e-PCR)
- UniSTS:119735

D1Smu9 (e-PCR)
- UniSTS:517829

RH144428 (e-PCR)
- UniSTS:233673

AU026593 (e-PCR)
- UniSTS:114129

D1Rat170 (e-PCR), detects polymorphism
- UniSTS:227047

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3T6 kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear androgen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor coactivator activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell activation	IEA Inferred from Electronic Annotation more info
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to carbohydrate stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to carbohydrate stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dibenzo-p-dioxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of D-glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of D-glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to angiotensin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
part_of spectrin	IEA Inferred from Electronic Annotation more info
part_of spectrin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein kinase C beta type

Names: PKC-beta; protein kinase C beta I; protein kinase C beta II; protein kinase C, beta 1

NP_001165776.1

EC 2.7.11.13

NP_036845.3

EC 2.7.11.13

XP_038957160.1

EC 2.7.11.13

XP_038957162.1

EC 2.7.11.13

XP_038957164.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172305.1 → NP_001165776.1 protein kinase C beta type isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

CK838368, JAXUCZ010000001, M19007

UniProtKB/TrEMBL

F1LS42

Conserved Domains (4) summary

cd04026
Location:159 → 289

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

smart00220
Location:342 → 600

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05616
Location:341 → 664

STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta

pfam00130
Location:102 → 152

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_012713.4 → NP_036845.3 protein kinase C beta type isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F1LS42

Related

ENSRNOP00000111645.1, ENSRNOT00000141500.1

Conserved Domains (4) summary

cd04026
Location:159 → 289

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

smart00220
Location:342 → 600

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05616
Location:341 → 663

STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta

pfam00130
Location:102 → 152

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

186263397..186594743

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101234.2 → XP_038957162.1 protein kinase C beta type isoform X2

UniProtKB/Swiss-Prot

P68403

UniProtKB/TrEMBL

F1LS42

Related

ENSRNOP00000016417.5, ENSRNOT00000016418.8

Conserved Domains (4) summary

cd04026
Location:159 → 289

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

cd05616
Location:341 → 664

STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta

cd20833
Location:35 → 92

C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

cd20836
Location:102 → 155

C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
XM_039101232.2 → XP_038957160.1 protein kinase C beta type isoform X1

UniProtKB/TrEMBL

F1LS42

Related

ENSRNOP00000073511.2, ENSRNOT00000078705.3

Conserved Domains (4) summary

cd04026
Location:159 → 289

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

cd05616
Location:341 → 663

STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta

cd20833
Location:35 → 92

C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

cd20836
Location:102 → 155

C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
XM_039101236.2 → XP_038957164.1 protein kinase C beta type isoform X3

UniProtKB/TrEMBL

A0A0G2K5Q0

Related

ENSRNOP00000016442.7, ENSRNOT00000016442.10

Conserved Domains (4) summary

cd04026
Location:113 → 243

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

cd05616
Location:295 → 617

STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta

cd20836
Location:56 → 109

C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

cl00040
Location:23 → 42

C1; protein kinase C conserved region 1 (C1 domain) superfamily