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    ptk2bb protein tyrosine kinase 2 beta, b [ Danio rerio (zebrafish) ]

    Gene ID: 245950, updated on 19-Jun-2024

    Summary

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    Official Symbol
    ptk2bbprovided by ZNC
    Official Full Name
    protein tyrosine kinase 2 beta, bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020507-1
    See related
    Ensembl:ENSDARG00000039577 AllianceGenome:ZFIN:ZDB-GENE-020507-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ptk2b; ptk2bl; im:6900512
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including epidermal growth factor receptor signaling pathway; innate immune response; and regulation of cell adhesion. Predicted to act upstream of or within several processes, including regulation of actin cytoskeleton reorganization; regulation of bone mineralization; and signal complex assembly. Predicted to be located in cell junction; cell projection; and cytoskeleton. Predicted to be active in dendritic spine and focal adhesion. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See ptk2bb in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19827379..19858931, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19927796..19959348, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-142k18.1 Neighboring gene cholinergic receptor, nicotinic, alpha 2b (neuronal) Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 5a Neighboring gene ras homolog family member J

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
    2. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, et al. Zebrafish, 2013 Sep. PMID 23234507, Free PMC Article
    3. Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Veerkamp J, et al. Dev Cell, 2013 Mar 25. PMID 23499359
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein tyrosine kinase 2 beta, b
    NP_997735.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423553.1 → NP_001410482.1  protein tyrosine kinase 2 beta, b

      Status: VALIDATED

      Source sequence(s)
      BX510657
      UniProtKB/TrEMBL
      A0A0R4IZK2, A0A8M1PF87, Q7T2P8

    2. NM_212570.1 → NP_997735.1  protein tyrosine kinase 2 beta, b

      See identical proteins and their annotated locations for NP_997735.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ490510
      UniProtKB/TrEMBL
      A0A0R4IZK2, A0A8M1PF87, Q7T2P8
      Related
      ENSDARP00000141667.2, ENSDART00000161579.2
      Conserved Domains (6) summary
      cd05056
      Location:410 → 678
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:38 → 261
      B41; Band 4.1 homologues
      cd13190
      Location:257 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:149 → 249
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:860 → 989
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:417 → 670
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      19827379..19858931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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