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    Zbtb38 zinc finger and BTB domain containing 38 [ Mus musculus (house mouse) ]

    Gene ID: 245007, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zbtb38provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 38provided by MGI
    Primary source
    MGI:MGI:2442866
    See related
    Ensembl:ENSMUSG00000040433 AllianceGenome:MGI:2442866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CIBZ; A930014K01Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and sequence-specific DNA binding activity. Predicted to be involved in DNA damage response and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleoplasm. Is expressed in genitourinary system. Orthologous to human ZBTB38 (zinc finger and BTB domain containing 38). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 2.7), ovary adult (RPKM 2.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb38 in Genome Data Viewer
    Location:
    9 E3.3; 9 50.71 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96564820..96613728, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96682767..96731675, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24963 Neighboring gene ubiquitin domain containing 2 pseudogene Neighboring gene RAS p21 protein activator 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96473690-96473991 Neighboring gene STARR-seq mESC enhancer starr_24966 Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene STARR-seq mESC enhancer starr_24967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:96570433-96570620 Neighboring gene STARR-seq mESC enhancer starr_24971 Neighboring gene RIKEN cDNA E030011O05 gene Neighboring gene STARR-positive B cell enhancer ABC_E9333 Neighboring gene STARR-seq mESC enhancer starr_24975 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96654988-96655289 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96659582-96659882 Neighboring gene RIKEN cDNA C430002N11 gene Neighboring gene STARR-positive B cell enhancer ABC_E11752 Neighboring gene STARR-seq mESC enhancer starr_24980 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene. Cai Y, et al. PLoS One, 2012. PMID 22427977, Free PMC Article
    2. The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression. Oikawa Y, et al. Cell Res, 2011 Nov. PMID 21625269, Free PMC Article
    3. Identification of a novel BTB-zinc finger transcriptional repressor, CIBZ, that interacts with CtBP corepressor. Sasai N, et al. Genes Cells, 2005 Sep. PMID 16115196
    4. ZBTB38 is dispensable for antibody responses. Wong R, et al. PLoS One, 2020. PMID 32956421, Free PMC Article
    5. Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis. Ocskó T, et al. Biochim Biophys Acta Gene Regul Mech, 2018 Nov. PMID 30343694

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression.
      Title: Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression.
    2. ZBTB38 is dispensable for antibody responses.
      Title: ZBTB38 is dispensable for antibody responses.
    3. Our studies demonstrate that Zbtb38 forms a molecular bridge between an arthritis-associated epimutation (DNA hypomethylation in Zbtb38 promoter) and transcriptional silencing of the IL1r2 gene in B cells. In this way, disease-associated DNA hypomethylation can support autoimmune arthritis by interfering with an anti-inflammatory pathway.
      Title: Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis.
    4. CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene.
      Title: CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene.
    5. CIBZ post-transcriptionally regulates the expression of Nanog.
      Title: CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog.
    6. CIBZ binds to a Myog promoter-proximal region and inhibits Myog transcription in a methylation-dependent manner.
      Title: The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression.
    7. CIBZ plays an important role by participating in the negative regulation of apoptosis in murine cells
      Title: Down-regulation of CIBZ, a novel substrate of caspase-3, induces apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 38
    Names
    CtBP-interacting BTB zinc finger protein
    Zenon homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359959.1 → NP_001346888.1  zinc finger and BTB domain-containing protein 38

      Status: VALIDATED

      Source sequence(s)
      AC121951, AK054096
      Consensus CDS
      CCDS40731.1
      UniProtKB/TrEMBL
      Q3LR78
      Conserved Domains (5) summary
      sd00017
      Location:1015 → 1035
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18223
      Location:15 → 128
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam00096
      Location:1041 → 1063
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1028 → 1051
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:340 → 400
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001359960.1 → NP_001346889.1  zinc finger and BTB domain-containing protein 38

      Status: VALIDATED

      Source sequence(s)
      AC121951, AK054529
      Consensus CDS
      CCDS40731.1
      UniProtKB/TrEMBL
      Q3LR78
      Conserved Domains (5) summary
      sd00017
      Location:1015 → 1035
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18223
      Location:15 → 128
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam00096
      Location:1041 → 1063
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1028 → 1051
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:340 → 400
      zf-C2H2_8; C2H2-type zinc ribbon

    3. NM_175537.3 → NP_780746.2  zinc finger and BTB domain-containing protein 38

      See identical proteins and their annotated locations for NP_780746.2

      Status: VALIDATED

      Source sequence(s)
      AC121951
      Consensus CDS
      CCDS40731.1
      UniProtKB/TrEMBL
      Q3LR78
      Related
      ENSMUSP00000091315.3, ENSMUST00000093798.9
      Conserved Domains (5) summary
      sd00017
      Location:1015 → 1035
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18223
      Location:15 → 128
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam00096
      Location:1041 → 1063
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1028 → 1051
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:340 → 400
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      96564820..96613728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511191.5 → XP_006511254.1  zinc finger and BTB domain-containing protein 38 isoform X3

      See identical proteins and their annotated locations for XP_006511254.1

      UniProtKB/TrEMBL
      Q3LR78
      Conserved Domains (5) summary
      sd00017
      Location:1015 → 1035
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18223
      Location:15 → 128
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam00096
      Location:1041 → 1063
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1028 → 1051
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:340 → 400
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_036155015.1 → XP_036010908.1  zinc finger and BTB domain-containing protein 38 isoform X3

      UniProtKB/TrEMBL
      Q3LR78
      Conserved Domains (5) summary
      sd00017
      Location:1015 → 1035
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18223
      Location:15 → 128
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam00096
      Location:1041 → 1063
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1028 → 1051
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:340 → 400
      zf-C2H2_8; C2H2-type zinc ribbon

    3. XM_006511189.5 → XP_006511252.1  zinc finger and BTB domain-containing protein 38 isoform X2

      Conserved Domains (6) summary
      sd00017
      Location:1029 → 1049
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1055 → 1077
      zf-C2H2; Zinc finger, C2H2 type
      cd18223
      Location:29 → 142
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam09507
      Location:725 → 955
      CDC27; DNA polymerase subunit Cdc27
      pfam13465
      Location:1042 → 1065
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:353 → 414
      zf-C2H2_8; C2H2-type zinc ribbon

    4. XM_006511193.5 → XP_006511256.1  zinc finger and BTB domain-containing protein 38 isoform X3

      See identical proteins and their annotated locations for XP_006511256.1

      UniProtKB/TrEMBL
      Q3LR78
      Conserved Domains (5) summary
      sd00017
      Location:1015 → 1035
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18223
      Location:15 → 128
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam00096
      Location:1041 → 1063
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1028 → 1051
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:340 → 400
      zf-C2H2_8; C2H2-type zinc ribbon

    5. XM_036155014.1 → XP_036010907.1  zinc finger and BTB domain-containing protein 38 isoform X1

      Conserved Domains (5) summary
      sd00017
      Location:1061 → 1081
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18223
      Location:61 → 174
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam00096
      Location:1087 → 1109
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1074 → 1097
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:386 → 446
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein Strain
    Heading Accession and Version

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