Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pin1provided by MGI
Official Full Name: peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1provided by MGI
Primary source: MGI:MGI:1346036
See related: Ensembl:ENSMUSG00000032171 AllianceGenome:MGI:1346036
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D9Bwg1161e; 0610025L01Rik
Summary: Enables several functions, including beta-catenin binding activity; peptidyl-prolyl cis-trans isomerase activity; and phosphoprotein binding activity. Involved in several processes, including negative regulation of amyloid-beta formation; protein peptidyl-prolyl isomerization; and protein stabilization. Acts upstream of or within regulation of cell population proliferation and regulation of cytokinesis. Located in cytosol and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including 2-cell stage embryo; gut; nucleus pulposus; and reproductive system. Used to study Alzheimer's disease. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 15.3), CNS E18 (RPKM 13.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.6 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20563335..20575008)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (20652118..20663712)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation.
Title: Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation.
Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity.
Title: Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity.
Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice.
Title: Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice.
PIN1 protects auditory hair cells from senescence via autophagy.
Title: PIN1 protects auditory hair cells from senescence via autophagy.
Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins, Leading to Secondary Hyperparathyroidism.
Title: Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins, Leading to Secondary Hyperparathyroidism.
Prolyl Isomerase, Pin1, Controls Meiotic Progression in Mouse Oocytes.
Title: Prolyl Isomerase, Pin1, Controls Meiotic Progression in Mouse Oocytes.
Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension.
Title: Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension.
[Prolyl Isomerase Pin1 Impacts on Metabolism in Muscle and Adipocytes].
Title: [Prolyl Isomerase Pin1 Impacts on Metabolism in Muscle and Adipocytes].
Death-associated protein kinase 1 mediates Abeta42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.
Title: Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.
The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.
Title: The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.

Submit: New GeneRIF Correction See all GeneRIFs (139)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Bwg1161e (e-PCR), detects polymorphism
- UniSTS:142740

AA962972 (e-PCR)
- UniSTS:247446

RH125187 (e-PCR)
- UniSTS:162009

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activating protein binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoserine residue binding	ISO Inferred from Sequence Orthology more info
enables phosphothreonine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IC Inferred by Curator more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein peptidyl-prolyl isomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein peptidyl-prolyl isomerization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation protein catabolic process at postsynapse	EXP Inferred from Experiment more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Names: PPIase Pin1; peptidyl-prolyl cis-trans isomerase Pin1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; rotamase Pin1

NP_001351424.1

EC 5.2.1.8

NP_075860.1

EC 5.2.1.8

XP_036010827.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364495.1 → NP_001351424.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC164565

Conserved Domains (2) summary

pfam00397
Location:7 → 37

WW; WW domain

cl26124
Location:53 → 129

Rotamase_2; PPIC-type PPIASE domain
NM_023371.4 → NP_075860.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 1

See identical proteins and their annotated locations for NP_075860.1

Status: VALIDATED

Source sequence(s)

AK003931, AK054045

Consensus CDS

CCDS22882.1

UniProtKB/Swiss-Prot

Q543B3, Q9QUR7

UniProtKB/TrEMBL

Q3UTI7

Related

ENSMUSP00000034689.7, ENSMUST00000034689.8

Conserved Domains (3) summary

COG0760
Location:55 → 161

SurA; Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]

pfam00397
Location:7 → 37

WW; WW domain

cl08278
Location:53 → 164

Rotamase_2; PPIC-type PPIASE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

20563335..20575008

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154934.1 → XP_036010827.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1

Conserved Domains (2) summary

pfam00397
Location:7 → 37

WW; WW domain

cl29122
Location:53 → 89

Rotamase_2; PPIC-type PPIASE domain