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    Gmcl1 germ cell-less, spermatogenesis associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 23885, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gmcl1provided by MGI
    Official Full Name
    germ cell-less, spermatogenesis associated 1provided by MGI
    Primary source
    MGI:MGI:1345156
    See related
    Ensembl:ENSMUSG00000001157 AllianceGenome:MGI:1345156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIP; Gcl; Gcl-1; glc-1; Btbd13; mglc-1; 2810049L19Rik
    Summary
    Predicted to enable cullin family protein binding activity and identical protein binding activity. Acts upstream of or within regulation of DNA-templated transcription. Located in nuclear envelope and nuclear matrix. Is expressed in several structures, including cerebral cortex; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including GMCL1 (germ cell-less 1, spermatogenesis associated). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 18.2), CNS E14 (RPKM 8.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gmcl1 in Genome Data Viewer
    Location:
    6 D1; 6 37.75 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86668750..86710377, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86691768..86733395, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E860 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86634487-86634670 Neighboring gene MAX dimerization protein 1 Neighboring gene small nuclear ribonucleoprotein 27 (U4/U6.U5) Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene annexin A4 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene AP2 associated kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells. Kimura T, et al. Biochem Biophys Res Commun, 1999 Aug 19. PMID 10448096
    2. Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility. Maekawa M, et al. Arch Histol Cytol, 2004 Nov. PMID 15700541
    3. Mouse germ cell-less as an essential component for nuclear integrity. Kimura T, et al. Mol Cell Biol, 2003 Feb. PMID 12556490, Free PMC Article
    4. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. de la Luna S, et al. EMBO J, 1999 Jan 4. PMID 9878064, Free PMC Article
    5. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Masuhara M, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927808

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gmcl1 interacts with the DP component of the E2F transcription factor.
      Title: Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.
    2. the mgcl-1 gene product appears to be essential for appropriate nuclear-lamina organization, which in turn is essential for normal sperm morphogenesis and chromatin remodeling.
      Title: Mouse germ cell-less as an essential component for nuclear integrity.
    3. mGCL-1 is a factor modulating MDM2-p53 axis by enhanced degradation of MDM2
      Title: Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    germ cell-less protein-like 1
    Names
    DP-interacting protein
    germ cell-less homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011818.3 → NP_035948.3  germ cell-less protein-like 1

      See identical proteins and their annotated locations for NP_035948.3

      Status: VALIDATED

      Source sequence(s)
      AF163665, AK004716, CJ122611, CX567687
      Consensus CDS
      CCDS20316.1
      UniProtKB/Swiss-Prot
      Q920G9, Q9DBW5, Q9QUP6
      UniProtKB/TrEMBL
      Q3UID6
      Related
      ENSMUSP00000001185.8, ENSMUST00000001185.14
      Conserved Domains (3) summary
      smart00225
      Location:107 → 206
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:211 → 281
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:96 → 203
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86668750..86710377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506056.4 → XP_006506119.1  germ cell-less protein-like 1 isoform X1

      Conserved Domains (1) summary
      cl28903
      Location:1 → 45
      BACK; BACK (BTB and C-terminal Kelch) domain

    RNA

    1. XR_377446.4 RNA Sequence

    2. XR_003956194.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920G9.2 GenPept UniProtKB/Swiss-Prot:Q920G9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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