Lilra5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lilra5provided by MGI
Official Full Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5provided by MGI
Primary source: MGI:MGI:3647196
See related: Ensembl:ENSMUSG00000070873 AllianceGenome:MGI:3647196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm4878; Lilrc1; EG232801; E030017K20
Summary: Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in several processes, including positive regulation of MAPK cascade; positive regulation of protein tyrosine kinase activity; and regulation of cytokine production. Predicted to be located in cell surface and extracellular space. Predicted to be active in plasma membrane. Is expressed in ganglia; medulla oblongata basal plate mantle layer; and ventral grey horn. Orthologous to human LILRA5 (leukocyte immunoglobulin like receptor A5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 1.6), liver E18 (RPKM 0.9) and 19 other tissues See more
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Genomic context

Location:: 7 A1; 7 2.45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4240643..4246689)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4237643..4243690)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leukocyte Immunoglobulin-like Receptor A5 Deletion Aggravates the Pathogenesis of Pseudomonas aeruginosa Keratitis by Promoting Proinflammatory Cytokines.
Title: Leukocyte Immunoglobulin-like Receptor A5 Deletion Aggravates the Pathogenesis of Pseudomonas aeruginosa Keratitis by Promoting Proinflammatory Cytokines.
LILRC1 and LILRC2 both have two extracellular Ig-like domains and a cytoplasmic tail devoid of any known signaling motifs. The transmembrane regions contain an arginine residue.
Title: Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inhibitory MHC class I receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte immunoglobulin-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081239.2 → NP_001074708.2 leukocyte immunoglobulin-like receptor precursor

Status: VALIDATED

Source sequence(s)

AC101941, AK086983, AY998482

Consensus CDS

CCDS51971.1

UniProtKB/TrEMBL

D3Z7A9

Related

ENSMUSP00000113091.2, ENSMUST00000117550.2

Conserved Domains (1) summary

cl11960
Location:123 → 219

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

4240643..4246689

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539764.5 → XP_006539827.1 leukocyte immunoglobulin-like receptor isoform X2

Conserved Domains (1) summary

cl11960
Location:123 → 219

Ig; Immunoglobulin domain
XM_006539765.5 → XP_006539828.1 leukocyte immunoglobulin-like receptor isoform X3

Conserved Domains (1) summary

cl11960
Location:28 → 118

Ig; Immunoglobulin domain
XM_006539763.5 → XP_006539826.1 leukocyte immunoglobulin-like receptor isoform X1

Conserved Domains (1) summary

cl11960
Location:111 → 207

Ig; Immunoglobulin domain