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    Klrh1 killer cell lectin-like receptor subfamily H, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 232415, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Klrh1provided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily H, member 1provided by MGI
    Primary source
    MGI:MGI:2685002
    See related
    Ensembl:ENSMUSG00000071158 AllianceGenome:MGI:2685002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm156
    Summary
    Predicted to enable (1->3)-beta-D-glucan binding activity; antigen binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including phagocytosis, recognition; positive regulation of cytokine production involved in immune response; and regulation of canonical NF-kappaB signal transduction. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Klrh1 in Genome Data Viewer
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129743531..129761233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129766568..129784270, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor family I member 2 Neighboring gene predicted gene, 57684 Neighboring gene STARR-seq mESC enhancer starr_17482 Neighboring gene killer cell lectin-like receptor, subfamily A, member 17 Neighboring gene predicted gene, 23977 Neighboring gene killer cell lectin-like receptor, subfamily A, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (1->3)-beta-D-glucan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis, recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily H, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014997.2 → NP_001014997.1  killer cell lectin-like receptor subfamily H, member 1 isoform 1

      See identical proteins and their annotated locations for NP_001014997.1

      Status: VALIDATED

      Source sequence(s)
      AB121775, AK138706
      Consensus CDS
      CCDS20595.1
      UniProtKB/TrEMBL
      Q58A37
      Related
      ENSMUSP00000093058.3, ENSMUST00000095409.3
      Conserved Domains (2) summary
      cd03593
      Location:100 → 216
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:31 → 114
      Ly49; Ly49-like protein, N-terminal region

    2. NM_001356340.1 → NP_001343269.1  killer cell lectin-like receptor subfamily H, member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK138706
      Consensus CDS
      CCDS90128.1
      UniProtKB/TrEMBL
      Q3UU75
      Related
      ENSMUSP00000113766.2, ENSMUST00000118532.8
      Conserved Domains (2) summary
      cd03593
      Location:100 → 171
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:31 → 114
      Ly49; Ly49-like protein, N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129743531..129761233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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