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    Tmem184a transmembrane protein 184a [ Mus musculus (house mouse) ]

    Gene ID: 231832, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem184aprovided by MGI
    Official Full Name
    transmembrane protein 184aprovided by MGI
    Primary source
    MGI:MGI:2385897
    See related
    Ensembl:ENSMUSG00000036687 AllianceGenome:MGI:2385897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sdmg1
    Summary
    Predicted to enable heparin binding activity and transmembrane transporter activity. Acts upstream of or within germ-line sex determination; regulation of protein localization; and regulation of secretion. Located in early endosome membrane and secretory granule membrane. Is expressed in several structures, including exocrine gland; gonad; gut; lung; and nose. Orthologous to human TMEM184A (transmembrane protein 184A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum adult (RPKM 77.6), stomach adult (RPKM 73.3) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem184a in Genome Data Viewer
    Location:
    5 G2; 5 78.81 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139790707..139805725, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139804951..139819969, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 1 Neighboring gene microRNA 7037 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140252978-140253165 Neighboring gene STARR-positive B cell enhancer ABC_E4803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140268130-140268313 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Neighboring gene STARR-seq mESC enhancer starr_14698 Neighboring gene proteasome (prosome, macropain) assembly chaperone 3 Neighboring gene predicted gene, 38727

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Svingen T, et al. Reproduction, 2007 May. PMID 17616727
    2. Sdmg1 is a component of secretory granules in mouse secretory exocrine tissues. Best D, et al. Dev Dyn, 2009 Jan. PMID 19097053
    3. Loss of R-spondin1 and Foxl2 amplifies female-to-male sex reversal in XX mice. Auguste A, et al. Sex Dev, 2011. PMID 22116255
    4. XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes. Lavery R, et al. Dev Biol, 2011 Jun 1. PMID 21466799
    5. Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Nef S, et al. Dev Biol, 2005 Nov 15. PMID 16214126

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30809, MGC37596

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within germ-line sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 184A
    Names
    sexually dimorphic expressed in male gonads 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161548.1 → NP_001155020.1  transmembrane protein 184A isoform 1

      See identical proteins and their annotated locations for NP_001155020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK050489, AK148454, CJ159994
      Consensus CDS
      CCDS51685.1
      UniProtKB/TrEMBL
      G3X923
      Related
      ENSMUSP00000035399.5, ENSMUST00000044002.10
      Conserved Domains (1) summary
      pfam03619
      Location:82 → 352
      Solute_trans_a; Organic solute transporter Ostalpha

    2. NM_144914.3 → NP_659163.3  transmembrane protein 184A isoform 2

      See identical proteins and their annotated locations for NP_659163.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK148454, BY230075
      Consensus CDS
      CCDS39354.1
      UniProtKB/Swiss-Prot
      Q3UFJ6, Q8BII8, Q8K1B0
      Related
      ENSMUSP00000106456.2, ENSMUST00000110832.8
      Conserved Domains (1) summary
      pfam03619
      Location:61 → 330
      Solute_trans_a; Organic solute transporter Ostalpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139790707..139805725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504670.5 → XP_006504733.1  transmembrane protein 184A isoform X1

      See identical proteins and their annotated locations for XP_006504733.1

      UniProtKB/Swiss-Prot
      Q3UFJ6, Q8BII8, Q8K1B0
      Conserved Domains (1) summary
      pfam03619
      Location:61 → 330
      Solute_trans_a; Organic solute transporter Ostalpha

    2. XM_006504671.3 → XP_006504734.1  transmembrane protein 184A isoform X1

      See identical proteins and their annotated locations for XP_006504734.1

      UniProtKB/Swiss-Prot
      Q3UFJ6, Q8BII8, Q8K1B0
      Conserved Domains (1) summary
      pfam03619
      Location:61 → 330
      Solute_trans_a; Organic solute transporter Ostalpha
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UFJ6.1 GenPept UniProtKB/Swiss-Prot:Q3UFJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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