U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tmem268 transmembrane protein 268 [ Mus musculus (house mouse) ]

    Gene ID: 230279, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmem268provided by MGI
    Official Full Name
    transmembrane protein 268provided by MGI
    Primary source
    MGI:MGI:1913920
    See related
    Ensembl:ENSMUSG00000045917 AllianceGenome:MGI:1913920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bM230C2.2; 6330416G13Rik
    Summary
    Predicted to be located in plasma membrane. Orthologous to human TMEM268 (transmembrane protein 268). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E18 (RPKM 6.3), colon adult (RPKM 4.8) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmem268 in Genome Data Viewer
    Location:
    4 B3; 4 34.02 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63472410..63504594)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63554595..63586357)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10437 Neighboring gene whirlin Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63141720-63141921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63150850-63151053 Neighboring gene STARR-positive B cell enhancer mm9_chr4:63205604-63205905 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 Neighboring gene predicted gene, 38592 Neighboring gene predicted gene, 24448 Neighboring gene STARR-positive B cell enhancer mm9_chr4:63263195-63263495 Neighboring gene testis expressed 53 Neighboring gene testis expressed 48

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling. Duan M, et al. EMBO Rep, 2024 Jun. PMID 38730209, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling.
      Title: Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC31101

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transmembrane protein 268
    Names
    transmembrane protein C9orf91 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356354.1 → NP_001343283.1  transmembrane protein 268

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AI593215, AK030466, AK031016, AK078066, BY067212, CJ046188
      Consensus CDS
      CCDS18261.1
      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Related
      ENSMUSP00000076891.5, ENSMUST00000077709.11
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    2. NM_001356355.1 → NP_001343284.1  transmembrane protein 268

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AI593215, AK030466, AK031016, AK078066, AL691484, BY067212, CJ046188
      Consensus CDS
      CCDS18261.1
      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    3. NM_144905.4 → NP_659154.2  transmembrane protein 268

      See identical proteins and their annotated locations for NP_659154.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AI593215, AK031016, AK078066, AL691484, BY171339
      Consensus CDS
      CCDS18261.1
      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Related
      ENSMUSP00000079211.3, ENSMUST00000080336.4
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63472410..63504594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537868.5 → XP_006537931.1  transmembrane protein 268 isoform X1

      See identical proteins and their annotated locations for XP_006537931.1

      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    2. XM_006537867.4 → XP_006537930.1  transmembrane protein 268 isoform X1

      See identical proteins and their annotated locations for XP_006537930.1

      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    3. XM_006537871.4 → XP_006537934.1  transmembrane protein 268 isoform X1

      See identical proteins and their annotated locations for XP_006537934.1

      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    4. XM_006537870.4 → XP_006537933.1  transmembrane protein 268 isoform X1

      See identical proteins and their annotated locations for XP_006537933.1

      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    5. XM_006537869.1 → XP_006537932.1  transmembrane protein 268 isoform X1

      See identical proteins and their annotated locations for XP_006537932.1

      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    6. XM_006537872.4 → XP_006537935.1  transmembrane protein 268 isoform X1

      See identical proteins and their annotated locations for XP_006537935.1

      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    7. XM_006537873.4 → XP_006537936.1  transmembrane protein 268 isoform X1

      See identical proteins and their annotated locations for XP_006537936.1

      UniProtKB/Swiss-Prot
      Q3TTV3, Q3UMC5, Q80VW1, Q80VW2, Q8BMN2, Q8C0I7, Q8CIJ7, Q8R239
      Conserved Domains (1) summary
      pfam14800
      Location:39 → 328
      DUF4481; Domain of unknown function (DUF4481)

    RNA

    1. XR_004941862.1 RNA Sequence

    2. XR_004941863.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R239.2 GenPept UniProtKB/Swiss-Prot:Q8R239

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools