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    Coq4 coenzyme Q4 [ Mus musculus (house mouse) ]

    Gene ID: 227683, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Coq4provided by MGI
    Official Full Name
    coenzyme Q4provided by MGI
    Primary source
    MGI:MGI:1098826
    See related
    Ensembl:ENSMUSG00000026798 AllianceGenome:MGI:1098826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D2Ertd97e
    Summary
    Predicted to be involved in ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; colon; gonad; heart; and lung. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7 and spastic ataxia. Orthologous to human COQ4 (coenzyme Q4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.4), duodenum adult (RPKM 13.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coq4 in Genome Data Viewer
    Location:
    2 B; 2 20.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29677505..29687947)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29787493..29797935)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proline rich transmembrane protein 1B Neighboring gene STARR-seq mESC enhancer starr_04071 Neighboring gene predicted gene 13547 Neighboring gene TruB pseudouridine (psi) synthase family member 2 Neighboring gene STARR-seq mESC enhancer starr_04073 Neighboring gene predicted gene, 52595 Neighboring gene solute carrier family 27 (fatty acid transporter), member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spermatogonia-dependent expression of testicular genes in mice. Tanaka K, et al. Dev Biol, 2002 Jun 15. PMID 12051830
    2. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
    3. Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis. Belogrudov GI, et al. Arch Biochem Biophys, 2001 Aug 1. PMID 11469793
    4. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
    5. Biochemistry of Mitochondrial Coenzyme Q Biosynthesis. Stefely JA, et al. Trends Biochem Sci, 2017 Oct. PMID 28927698, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • A330041N06

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquinone biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquinone biosynthesis complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquinone biosynthesis complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
    Names
    coenzyme Q biosynthesis protein 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178693.5 → NP_848808.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

      See identical proteins and their annotated locations for NP_848808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK050459, AK163270, AL845323
      Consensus CDS
      CCDS15857.1
      UniProtKB/Swiss-Prot
      Q8BGB8
      UniProtKB/TrEMBL
      B9EID1, Q8BLS2
      Related
      ENSMUSP00000028137.4, ENSMUST00000028137.10
      Conserved Domains (1) summary
      pfam05019
      Location:63 → 259
      Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

    RNA

    1. NR_145503.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice sites in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK163270, AL845323
      Related
      ENSMUST00000143616.8

    2. NR_145504.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK050459, AK163270, AL845323

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29677505..29687947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239076.4 → XP_011237378.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X2

      UniProtKB/TrEMBL
      D6RJJ8
      Related
      ENSMUSP00000135687.2, ENSMUST00000176348.8
      Conserved Domains (1) summary
      cl02093
      Location:63 → 126
      Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

    2. XM_017317287.3 → XP_017172776.1  ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q8BLS2
      Conserved Domains (1) summary
      pfam05019
      Location:63 → 258
      Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

    RNA

    1. XR_001782055.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGB8.1 GenPept UniProtKB/Swiss-Prot:Q8BGB8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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