Slco4c1 solute carrier organic anion transporter family, member 4C1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slco4c1provided by MGI
Official Full Name: solute carrier organic anion transporter family, member 4C1provided by MGI
Primary source: MGI:MGI:2442784
See related: Ensembl:ENSMUSG00000040693 AllianceGenome:MGI:2442784
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OATPX; OATP-H; oatp-R; OATP-M1; OATP4C1; PRO2176; SLC21A20; 9530051F04; C330017E21Rik
Summary: Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including forebrain; genitourinary system; integumental system; respiratory system; and sensory organ. Orthologous to human SLCO4C1 (solute carrier organic anion transporter family member 4C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in genital fat pad adult (RPKM 3.6), lung adult (RPKM 3.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 47.76 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (96744918..96800027, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (96816270..96872193, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slco4c1 (e-PCR), detects polymorphism
- UniSTS:532568

NoName (e-PCR)
- UniSTS:234180

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 4C1

Names: organic anion transporting polypeptide 4C1; solute carrier family 21 member 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172658.3 → NP_766246.1 solute carrier organic anion transporter family member 4C1

See identical proteins and their annotated locations for NP_766246.1

Status: PROVISIONAL

Source sequence(s)

AK049253

Consensus CDS

CCDS35675.1

UniProtKB/Swiss-Prot

Q8BGD4

Related

ENSMUSP00000071875.5, ENSMUST00000071985.6

Conserved Domains (3) summary

cd06174
Location:120 → 473

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:496 → 549

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:102 → 662

OATP; Organic Anion Transporter Polypeptide (OATP) family