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    Onecut2 one cut domain, family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 225631, updated on 28-Oct-2024

    Summary

    Official Symbol
    Onecut2provided by MGI
    Official Full Name
    one cut domain, family member 2provided by MGI
    Primary source
    MGI:MGI:1891408
    See related
    Ensembl:ENSMUSG00000045991 AllianceGenome:MGI:1891408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oc2; OC-2; C730009D12
    Summary
    Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; peripheral nervous system neuron development; and positive regulation of mesenchymal stem cell migration. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future brain; genitourinary system; gut; and retina. Orthologous to human ONECUT2 (one cut homeobox 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in liver adult (RPKM 3.0), duodenum adult (RPKM 1.9) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Onecut2 in Genome Data Viewer
    Location:
    18 E1; 18 37.33 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (64473098..64531559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64340032..64398488)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 Neighboring gene ribosomal protein S15, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_44803 Neighboring gene STARR-seq mESC enhancer starr_44804 Neighboring gene STARR-seq mESC enhancer starr_44805 Neighboring gene STARR-seq mESC enhancer starr_44806 Neighboring gene predicted gene, 36804 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124203

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endocrine pancreas development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within liver development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of mesenchymal stem cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within pancreas development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within peripheral nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mesenchymal stem cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell-matrix adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    one cut domain family member 2
    Names
    one cut homeobox 2
    transcription factor ONECUT-2
    transcription factor ONECUT2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194268.3NP_919244.2  one cut domain family member 2

      See identical proteins and their annotated locations for NP_919244.2

      Status: VALIDATED

      Source sequence(s)
      AC102106
      Consensus CDS
      CCDS29302.2
      UniProtKB/Swiss-Prot
      Q6XBJ3
      UniProtKB/TrEMBL
      Q3ZAT5
      Related
      ENSMUSP00000135692.3, ENSMUST00000175965.10
      Conserved Domains (2) summary
      smart00389
      Location:427482
      HOX; Homeodomain
      pfam02376
      Location:332404
      CUT; CUT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      64473098..64531559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250441.1XP_030106301.1  one cut domain family member 2 isoform X1

      Conserved Domains (1) summary
      pfam02376
      Location:332400
      CUT; CUT domain