ZSCAN23 zinc finger and SCAN domain containing 23 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZSCAN23provided by HGNC
Official Full Name: zinc finger and SCAN domain containing 23provided by HGNC
Primary source: HGNC:HGNC:21193
See related: Ensembl:ENSG00000187987 AllianceGenome:HGNC:21193
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZNF390; ZNF453; dJ29K1.3; dJ29K1.3.1
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 6p22.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (28421400..28443491, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (28290130..28314932, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (28400432..28411268, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling.
Title: Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and SCAN domain-containing protein 23

Names: zinc finger protein 390; zinc finger protein 453

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012455.2 → NP_001012458.1 zinc finger and SCAN domain-containing protein 23

See identical proteins and their annotated locations for NP_001012458.1

Status: VALIDATED

Source sequence(s)

AL833347, BX283350, Z98745

Consensus CDS

CCDS47393.1

UniProtKB/Swiss-Prot

Q3MJ62, Q96KV9

Related

ENSP00000289788.4, ENST00000289788.5

Conserved Domains (6) summary

smart00431
Location:44 → 156

SCAN; leucine rich region

COG5048
Location:215 → 384

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:251 → 271

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:249 → 271

zf-C2H2; Zinc finger, C2H2 type

pfam02023
Location:45 → 132

SCAN; SCAN domain

pfam13465
Location:264 → 288

zf-H2C2_2; Zinc-finger double domain