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    Btf3 basic transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 218490, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Btf3provided by MGI
    Official Full Name
    basic transcription factor 3provided by MGI
    Primary source
    MGI:MGI:1202875
    See related
    Ensembl:ENSMUSG00000021660 AllianceGenome:MGI:1202875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700054E11Rik
    Summary
    Acts upstream of or within in utero embryonic development. Predicted to be located in cytoplasm. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human BTF3 (basic transcription factor 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 136.7), placenta adult (RPKM 125.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Btf3 in Genome Data Viewer
    Location:
    13 D1; 13 51.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98446405..98453514, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98309897..98317006, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat family A member 2 Neighboring gene predicted gene 21976 Neighboring gene STARR-seq mESC enhancer starr_35417 Neighboring gene STARR-seq mESC enhancer starr_35418 Neighboring gene predicted gene 9828 Neighboring gene STARR-seq mESC enhancer starr_35419 Neighboring gene forkhead box D1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An insertional mutation in the BTF3 transcription factor gene leads to an early postimplantation lethality in mice. Deng JM, et al. Transgenic Res, 1995 Jul. PMID 7655515
    2. Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity. Zeng KW, et al. Signal Transduct Target Ther, 2021 Feb 19. PMID 33602894, Free PMC Article
    3. Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro. Bae S, et al. Int J Mol Med, 2008 Mar. PMID 18288386
    4. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. De Cegli R, et al. Nucleic Acids Res, 2013 Jan. PMID 23180766, Free PMC Article
    5. A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. Fu H, et al. J Neurosci, 2009 Sep 9. PMID 19741146, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity.
      Title: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity.
    2. Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10]
      Title: Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nascent polypeptide-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nascent polypeptide-associated complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor BTF3
    Names
    NAC-beta
    RNA polymerase B transcription factor 3
    nascent polypeptide-associated complex subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170540.1 → NP_001164011.1  transcription factor BTF3 isoform 2

      See identical proteins and their annotated locations for NP_001164011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK139664, BC064010, CJ073405
      Consensus CDS
      CCDS49340.1
      UniProtKB/TrEMBL
      Q3UJR8
      Related
      ENSMUSP00000118093.2, ENSMUST00000152704.8
      Conserved Domains (1) summary
      cd22055
      Location:9 → 125
      NAC_BTF3; basal transcription factor BTF3

    2. NM_145455.3 → NP_663430.2  transcription factor BTF3 isoform 1

      See identical proteins and their annotated locations for NP_663430.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BC064010
      Consensus CDS
      CCDS26714.1
      UniProtKB/Swiss-Prot
      Q64152, Q64153, Q6GU63, Q6P3F3
      Related
      ENSMUSP00000022163.9, ENSMUST00000022163.15
      Conserved Domains (1) summary
      pfam01849
      Location:85 → 138
      NAC; NAC domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      98446405..98453514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64152.3 GenPept UniProtKB/Swiss-Prot:Q64152

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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