B4galt7 beta-1,4-galactosyltransferase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: B4galt7provided by MGI
Official Full Name: beta-1,4-galactosyltransferase 7provided by MGI
Primary source: MGI:MGI:2384987
See related: Ensembl:ENSMUSG00000021504 AllianceGenome:MGI:2384987
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: XGPT; XGalT-1
Summary: Enables xylosylprotein 4-beta-galactosyltransferase activity. Involved in glycosaminoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 11.8), limb E14.5 (RPKM 11.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.06 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55747709..55758258)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (55599896..55610443)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

surface GalT I might negatively regulate mammary epithelial cell survival
Title: Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase I.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables galactosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables xylosylprotein 4-beta-galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables xylosylprotein 4-beta-galactosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xylosylprotein 4-beta-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables xylosylprotein 4-beta-galactosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycosaminoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosaminoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycosaminoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in supramolecular fiber organization	ISO Inferred from Sequence Orthology more info
involved_in supramolecular fiber organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: beta-1,4-galactosyltransferase 7

Names: UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7; UDP-galactose:beta-xylose beta-1,4-galactosyltransferase; b4Gal-T7; beta-1,4-GalTase 7; beta4Gal-T7; proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; xylosylprotein 4-beta-galactosyltransferase; xylosylprotein beta-1,4-galactosyltransferase; xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)

NP_001298066.1

EC 2.4.1.133

NP_666157.1

EC 2.4.1.133

XP_036013888.1

EC 2.4.1.133

XP_036013889.1

EC 2.4.1.133

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311137.1 → NP_001298066.1 beta-1,4-galactosyltransferase 7 isoform 2

See identical proteins and their annotated locations for NP_001298066.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

BC055703, BF455923

Consensus CDS

CCDS79190.1

UniProtKB/TrEMBL

Q3UR73

Related

ENSMUSP00000098327.4, ENSMUST00000100764.10

Conserved Domains (1) summary

cd00899
Location:92 → 280

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
NM_146045.2 → NP_666157.1 beta-1,4-galactosyltransferase 7 isoform 1

See identical proteins and their annotated locations for NP_666157.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK146855, BC055703, BF455923

Consensus CDS

CCDS26550.1

UniProtKB/Swiss-Prot

Q7TNU3, Q8R087

UniProtKB/TrEMBL

Q3TAW1, Q3UR73

Related

ENSMUSP00000068532.7, ENSMUST00000064701.8

Conserved Domains (1) summary

cd00899
Location:92 → 315

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

55747709..55758258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157995.1 → XP_036013888.1 beta-1,4-galactosyltransferase 7 isoform X1

UniProtKB/TrEMBL

Q3UR73

Related

ENSMUSP00000123292.2, ENSMUST00000133176.8

Conserved Domains (1) summary

cd00899
Location:36 → 259

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
XM_036157996.1 → XP_036013889.1 beta-1,4-galactosyltransferase 7 isoform X2

UniProtKB/TrEMBL

D3Z065

Conserved Domains (1) summary

cd00899
Location:36 → 224

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids