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    Mms22l MMS22-like, DNA repair protein [ Mus musculus (house mouse) ]

    Gene ID: 212377, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mms22lprovided by MGI
    Official Full Name
    MMS22-like, DNA repair proteinprovided by MGI
    Primary source
    MGI:MGI:2684980
    See related
    Ensembl:ENSMUSG00000045751 AllianceGenome:MGI:2684980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm134; F730047E07Rik
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; protein localization to chromatin; and replication fork processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of FACT complex and MCM complex. Predicted to be active in nuclear replication fork and site of double-strand break. Is expressed in cerebral cortex ventricular layer. Orthologous to human MMS22L (MMS22 like, DNA repair protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 6.1), CNS E11.5 (RPKM 6.0) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mms22l in Genome Data Viewer
    Location:
    4 A3; 4 10.36 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (24496451..24602950)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (24496451..24602950)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09772 Neighboring gene predicted gene, 31145 Neighboring gene predicted gene 27243 Neighboring gene STARR-seq mESC enhancer starr_09774 Neighboring gene tubulin, beta 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09775 Neighboring gene STARR-seq mESC enhancer starr_09776 Neighboring gene STARR-seq mESC enhancer starr_09777 Neighboring gene STARR-seq mESC enhancer starr_09778 Neighboring gene STARR-seq mESC enhancer starr_09780 Neighboring gene STARR-seq mESC enhancer starr_09781 Neighboring gene kelch-like 32 Neighboring gene predicted gene, 31436 Neighboring gene predicted gene, 31379

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
    2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FACT complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of MCM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MCM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein MMS22-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199467.3 → NP_955761.2  protein MMS22-like

      See identical proteins and their annotated locations for NP_955761.2

      Status: VALIDATED

      Source sequence(s)
      AK089531, AK164069, BC094429, BX296536, CK639437
      Consensus CDS
      CCDS18006.2
      UniProtKB/Swiss-Prot
      B1AUR6, B7ZN61, D3YXA0, Q6R5F9, Q80UT0
      UniProtKB/TrEMBL
      G8JL47
      Related
      ENSMUSP00000103857.3, ENSMUST00000108222.9
      Conserved Domains (2) summary
      pfam14910
      Location:26 → 730
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:849 → 1225
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

    RNA

    1. NR_149739.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK089531, AK164069, AL671913, BC094429, BE623427, BX296536, CK639437

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      24496451..24602950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537730.4 → XP_006537793.1  protein MMS22-like isoform X1

      See identical proteins and their annotated locations for XP_006537793.1

      UniProtKB/TrEMBL
      G8JL47
      Conserved Domains (2) summary
      pfam14910
      Location:26 → 730
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:850 → 1226
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

    2. XM_036163937.1 → XP_036019830.1  protein MMS22-like isoform X1

      UniProtKB/TrEMBL
      G8JL47
      Conserved Domains (2) summary
      pfam14910
      Location:26 → 730
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:850 → 1226
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

    3. XM_036163938.1 → XP_036019831.1  protein MMS22-like isoform X2

      UniProtKB/Swiss-Prot
      B1AUR6, B7ZN61, D3YXA0, Q6R5F9, Q80UT0
      UniProtKB/TrEMBL
      G8JL47
      Conserved Domains (2) summary
      pfam14910
      Location:26 → 730
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:849 → 1225
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

    4. XM_036163939.1 → XP_036019832.1  protein MMS22-like isoform X3

      Conserved Domains (2) summary
      pfam14910
      Location:11 → 369
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:489 → 865
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

    5. XM_011249970.4 → XP_011248272.1  protein MMS22-like isoform X4

      Conserved Domains (2) summary
      pfam14910
      Location:29 → 249
      MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
      pfam14911
      Location:369 → 745
      MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

    RNA

    1. XR_003954900.1 RNA Sequence

    2. XR_003954899.1 RNA Sequence

    3. XR_004941857.1 RNA Sequence

      Related
      ENSMUST00000154349.9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AUR6.1 GenPept UniProtKB/Swiss-Prot:B1AUR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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