Mapre2 microtubule-associated protein, RP/EB family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapre2provided by MGI
Official Full Name: microtubule-associated protein, RP/EB family, member 2provided by MGI
Primary source: MGI:MGI:106271
See related: Ensembl:ENSMUSG00000024277 AllianceGenome:MGI:106271
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EB1; EB2; RP1; D18Abb1e; C820009F03Rik
Summary: Enables microtubule plus-end binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of ARF protein signal transduction; positive regulation of focal adhesion disassembly; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE2 (microtubule associated protein RP/EB family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 49.0), cerebellum adult (RPKM 47.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A2; 18 12.08 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (23885390..24026918)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (23752333..23893861)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination.
Title: E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination.
Knockdown of HAX1 and EB2 in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration.
Title: Regulation of Focal Adhesion Dynamics and Cell Motility by the EB2 and Hax1 Protein Complex.
Thus, we suggest that EB1 could complement MAP1B function during neural development.
Title: End binding protein-1 (EB1) complements microtubule-associated protein-1B during axonogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Abb1e (e-PCR), detects polymorphism
- UniSTS:142183

AI314113 (e-PCR)
- UniSTS:160728

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ARF protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of focal adhesion disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of keratinocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: microtubule-associated protein RP/EB family member 2

Names: APC-binding protein EB1; APC-binding protein EB2; T-cell activation protein, EB1 family, member 2; end-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162941.1 → NP_001156413.1 microtubule-associated protein RP/EB family member 2 isoform 2

See identical proteins and their annotated locations for NP_001156413.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC132419, AK028823, AK148954

Consensus CDS

CCDS50237.1

UniProtKB/TrEMBL

D3YYK8

Related

ENSMUSP00000111496.2, ENSMUST00000115830.8

Conserved Domains (3) summary

pfam00307
Location:49 → 133

CH; Calponin homology (CH) domain

pfam03271
Location:252 → 289

EB1; EB1-like C-terminal motif

cl01709
Location:107 → 164

PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold
NM_001162942.1 → NP_001156414.1 microtubule-associated protein RP/EB family member 2 isoform 3

See identical proteins and their annotated locations for NP_001156414.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC132419, AC145084, AI325879, AK028823, AK148954

Consensus CDS

CCDS50238.1

UniProtKB/TrEMBL

D3YYK8, E9Q6X0

Related

ENSMUSP00000128040.2, ENSMUST00000170802.8

Conserved Domains (1) summary

COG5217
Location:16 → 270

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
NM_153058.4 → NP_694698.3 microtubule-associated protein RP/EB family member 2 isoform 1

See identical proteins and their annotated locations for NP_694698.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC132419, AK148954

Consensus CDS

CCDS29095.1

UniProtKB/Swiss-Prot

Q3UF61, Q8BLZ6, Q8BYR6, Q8C177, Q8K109, Q8R001

Related

ENSMUSP00000025127.4, ENSMUST00000025127.5

Conserved Domains (1) summary

cl26556
Location:58 → 312

EB1; EB1-like C-terminal motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

23885390..24026918

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525744.3 → XP_006525807.1 microtubule-associated protein RP/EB family member 2 isoform X1

See identical proteins and their annotated locations for XP_006525807.1

UniProtKB/TrEMBL

D3YYK8, E9Q6X0

Conserved Domains (1) summary

COG5217
Location:16 → 270

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
XM_036161047.1 → XP_036016940.1 microtubule-associated protein RP/EB family member 2 isoform X1

UniProtKB/TrEMBL

D3YYK8, E9Q6X0

Conserved Domains (1) summary

COG5217
Location:16 → 270

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
XM_006525745.2 → XP_006525808.1 microtubule-associated protein RP/EB family member 2 isoform X2

UniProtKB/TrEMBL

D3YYK8

Conserved Domains (1) summary

COG5217
Location:29 → 259

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]