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    RDM1 RAD52 motif containing 1 [ Homo sapiens (human) ]

    Gene ID: 201299, updated on 28-Oct-2024

    Summary

    Official Symbol
    RDM1provided by HGNC
    Official Full Name
    RAD52 motif containing 1provided by HGNC
    Primary source
    HGNC:HGNC:19950
    See related
    Ensembl:ENSG00000278023 MIM:612896; AllianceGenome:HGNC:19950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAD52B
    Summary
    This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 2.2), lymph node (RPKM 0.3) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RDM1 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35918080..35930773, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36865987..36878680, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34245084..34257777, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37, member A3 pseudogene Neighboring gene leucine-rich repeat-containing protein 37B-like Neighboring gene lysozyme like 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:34288003-34288221 Neighboring gene C-C motif chemokine ligand 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33977

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    RAD52 motif-containing protein 1
    Names
    RAD52 homolog B
    RAD52 motif 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034836.2NP_001030008.1  RAD52 motif-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001030008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant(2) differs in the 3' coding region and UTR, compared to variant 1. This results in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC004675, AC244100, BM559857
      Consensus CDS
      CCDS42299.1
      UniProtKB/TrEMBL
      B4DZ74, C9JYC6
      Related
      ENSP00000482288.1, ENST00000613308.4
      Conserved Domains (1) summary
      cd12364
      Location:1595
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    2. NM_001163120.2NP_001156592.1  RAD52 motif-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001156592.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3, also known as zeta) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BU599050, BX376188, EF488478
      Consensus CDS
      CCDS54110.1
      UniProtKB/Swiss-Prot
      Q8NG50
      Related
      ENSP00000483387.1, ENST00000612980.4
      Conserved Domains (1) summary
      cd12364
      Location:1595
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    3. NM_001163121.2NP_001156593.1  RAD52 motif-containing protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001156593.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4, also known as gamma) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BU599050, BX376188, EF488475
      Consensus CDS
      CCDS54111.1
      UniProtKB/Swiss-Prot
      Q8NG50
      Related
      ENSP00000478915.1, ENST00000616596.4
      Conserved Domains (1) summary
      cd12364
      Location:1595
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    4. NM_001163122.1NP_001156594.1  RAD52 motif-containing protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001156594.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5, also known as DeltaN-gamma) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AW138754, BX376188, EF488481
      Consensus CDS
      CCDS59281.1
      UniProtKB/Swiss-Prot
      Q8NG50
      Related
      ENSP00000483933.1, ENST00000619828.4
      Conserved Domains (1) summary
      cd12364
      Location:1072
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    5. NM_001163124.1NP_001156596.1  RAD52 motif-containing protein 1 isoform 6

      See identical proteins and their annotated locations for NP_001156596.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (6, also known as DeltaN-zeta) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AW138754, BX376188, EF488473
      Consensus CDS
      CCDS59280.1
      UniProtKB/Swiss-Prot
      Q8NG50
      Related
      ENSP00000479622.1, ENST00000617591.4
      Conserved Domains (1) summary
      cd12364
      Location:1072
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    6. NM_001163125.1NP_001156597.1  RAD52 motif-containing protein 1 isoform 7

      See identical proteins and their annotated locations for NP_001156597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and coding sequence and lacks an alternate internal coding exon compared to variant 1. The resulting isoform (7) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AA761980, AC244100, AW138754
      Consensus CDS
      CCDS54108.1
      UniProtKB/Swiss-Prot
      Q8NG50
      Related
      ENSP00000480131.1, ENST00000615378.1
      Conserved Domains (1) summary
      cd12364
      Location:1072
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    7. NM_001163130.1NP_001156602.1  RAD52 motif-containing protein 1 isoform 8

      See identical proteins and their annotated locations for NP_001156602.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (8, also known as DeltaN-alpha) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AW138754, BX376188, EF488479
      Consensus CDS
      CCDS54109.1
      UniProtKB/Swiss-Prot
      Q8NG50
      Related
      ENSP00000479310.1, ENST00000619262.4
      Conserved Domains (1) summary
      cd12364
      Location:1072
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    8. NM_001330194.2NP_001317123.1  RAD52 motif-containing protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC244100
      Consensus CDS
      CCDS82109.1
      UniProtKB/Swiss-Prot
      Q8NG50
      Related
      ENSP00000482981.1, ENST00000619193.4
      Conserved Domains (1) summary
      cd12364
      Location:1595
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
    9. NM_145654.4NP_663629.1  RAD52 motif-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_663629.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1, also known as isoform alpha).
      Source sequence(s)
      AB080728, BU599050, BX376188
      Consensus CDS
      CCDS11301.1
      UniProtKB/Swiss-Prot
      A0JP55, A8MV46, A8MY68, A8MZ92, A8RCS5, A8RCT0, A8RCT5, A8RCT8, A8RCU3, A8RCU8, A8RCW0, A8RCW5, Q8NG50
      Related
      ENSP00000483549.1, ENST00000620284.5
      Conserved Domains (1) summary
      cd12364
      Location:1595
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins

    RNA

    1. NR_027996.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9, also known as delta) lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
      Source sequence(s)
      BU599050, BX376188, EF488476
    2. NR_027997.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10, also known as beta) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
      Source sequence(s)
      BU599050, BX376188, EF488474
    3. NR_027998.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11, also known as epsilon) lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
      Source sequence(s)
      BU599050, BX376188, EF488477
    4. NR_027999.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12, also known as DeltaN-epsilon) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
      Source sequence(s)
      AW138754, BX376188, EF488482
    5. NR_028000.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13, also known as DeltaN-beta) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
      Source sequence(s)
      AW138754, BX376188, EF488480

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      35918080..35930773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524509.3XP_011522811.1  RAD52 motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011522811.1

      Conserved Domains (1) summary
      cd12364
      Location:1595
      RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      152612..165305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329276.1XP_054185251.1  RAD52 motif-containing protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36865987..36878680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315413.1XP_054171388.1  RAD52 motif-containing protein 1 isoform X1