Rhd Rh blood group, D antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhdprovided by MGI
Official Full Name: Rh blood group, D antigenprovided by MGI
Primary source: MGI:MGI:1202882
See related: Ensembl:ENSMUSG00000028825 AllianceGenome:MGI:1202882
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rh; Rhl1; Rhced
Summary: Predicted to enable ammonium channel activity. Acts upstream of or within ammonium transmembrane transport; erythrocyte development; and multicellular organismal-level iron ion homeostasis. Located in membrane. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Rh isoimmunization. Orthologous to human RHCE (Rh blood group CcEe antigens) and RHD (Rh blood group D antigen). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E14.5 (RPKM 179.9), liver E14 (RPKM 141.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 67.13 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (134591875..134623483)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134864536..134896172)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491359

Rhd (e-PCR), detects polymorphism
- UniSTS:498277

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ammonium homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ammonium transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ankyrin-1 complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: blood group Rh(D) polypeptide

Names: Rh blood group protein; Rh-like polypeptide; Rhesus blood group CE and D; erythrocyte membrane glycoprotein Rh30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.