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    Tmem199 transmembrane protein 199 [ Mus musculus (house mouse) ]

    Gene ID: 195040, updated on 18-Sep-2024

    Summary

    Official Symbol
    Tmem199provided by MGI
    Official Full Name
    transmembrane protein 199provided by MGI
    Primary source
    MGI:MGI:2144113
    See related
    Ensembl:ENSMUSG00000051232 AllianceGenome:MGI:2144113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in cellular cation homeostasis; cellular response to increased oxygen levels; and lysosomal protein catabolic process. Predicted to be located in COPI-coated vesicle membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIp. Orthologous to human TMEM199 (transmembrane protein 199). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 17.9), CNS E18 (RPKM 15.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmem199 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78397881..78402994, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78507055..78512168, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene vitronectin Neighboring gene SEBOX homeobox Neighboring gene polymerase (DNA-directed), delta interacting protein 2 Neighboring gene tumor necrosis factor, alpha-induced protein 1 (endothelial)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables oxysterol binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to increased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to increased oxygen levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lysosomal lumen acidification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosomal lumen acidification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lysosomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in COPI-coated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in COPI-coated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of vacuolar proton-transporting V-type ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of vacuolar proton-transporting V-type ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 199
    Names
    RE40914p

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199199.3NP_954669.2  transmembrane protein 199

      See identical proteins and their annotated locations for NP_954669.2

      Status: VALIDATED

      Source sequence(s)
      BC050977, BY255000
      Consensus CDS
      CCDS25108.1
      UniProtKB/Swiss-Prot
      Q5SYH2
      UniProtKB/TrEMBL
      B2RV69, Q3TZ80
      Related
      ENSMUSP00000058599.8, ENSMUST00000052566.8
      Conserved Domains (2) summary
      pfam11712
      Location:78202
      Vma12; Endoplasmic reticulum-based factor for assembly of V-ATPase
      pfam12240
      Location:974
      Angiomotin_C; Angiomotin C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78397881..78402994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)