U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    tbh-1 [ Caenorhabditis elegans ]

    Gene ID: 181639, updated on 11-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tbh-1
    Primary source
    WormBase:WBGene00006541
    Locus tag
    CELE_H13N06.6
    See related
    AllianceGenome:WB:WBGene00006541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables tyramine-beta hydroxylase activity. Involved in octopamine biosynthetic process. Located in synapse. Is expressed in intestine; nervous system; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (15500256..15504895, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene VWFA domain-containing protein Neighboring gene Trehalose-phosphatase Neighboring gene Cytochrome b5 heme-binding domain-containing protein;sulfite oxidase Neighboring gene Uncharacterized protein Neighboring gene Zinc transporter zipt-7.2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Octopamine connects nutrient cues to lipid metabolism upon nutrient deprivation. Tao J, et al. Sci Adv, 2016 May. PMID 27386520, Free PMC Article
    2. Coordination of behavioral hierarchies during environmental transitions in Caenorhabditis elegans. Vidal-Gadea AG, et al. Worm, 2012 Jan. PMID 23525841, Free PMC Article
    3. Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system. Alkema MJ, et al. Neuron, 2005 Apr 21. PMID 15848803
    4. Enhancement of odor avoidance regulated by dopamine signaling in Caenorhabditis elegans. Kimura KD, et al. J Neurosci, 2010 Dec 1. PMID 21123582, Free PMC Article
    5. Starvation induces cAMP response element-binding protein-dependent gene expression through octopamine-Gq signaling in Caenorhabditis elegans. Suo S, et al. J Neurosci, 2006 Oct 4. PMID 17021164, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dopamine beta-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dopamine beta-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyramine-beta hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in norepinephrine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in octopamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in octopamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in secretory granule membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DOMON domain-containing protein;Tyramine beta-hydroxylase
    NP_001257264.1
    • Partially confirmed by transcript evidence
    NP_001257265.1
    • Confirmed by transcript evidence
    NP_001300365.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15500256..15504895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270336.3 → NP_001257265.1  Tyramine beta-hydroxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257265.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTQ6
      Conserved Domains (3) summary
      pfam01082
      Location:198 → 315
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03351
      Location:30 → 143
      DOMON; DOMON domain
      pfam03712
      Location:336 → 490
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    2. NM_001270335.2 → NP_001257264.1  Tyramine beta-hydroxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257264.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6KRQ4, Q9XTQ6
      Conserved Domains (3) summary
      pfam01082
      Location:270 → 387
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03351
      Location:102 → 215
      DOMON; DOMON domain
      pfam03712
      Location:408 → 562
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    3. NM_001313436.5 → NP_001300365.1  DOMON domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATC0
      Conserved Domains (3) summary
      smart00664
      Location:51 → 182
      DoH; Possible catecholamine-binding domain present in a variety of eukaryotic proteins
      pfam01082
      Location:219 → 337
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:357 → 511
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTQ6.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools