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    Cd200 CD200 molecule [ Mus musculus (house mouse) ]

    Gene ID: 17470, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cd200provided by MGI
    Official Full Name
    CD200 moleculeprovided by MGI
    Primary source
    MGI:MGI:1196990
    See related
    Ensembl:ENSMUSG00000022661 AllianceGenome:MGI:1196990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OX2; Mox2
    Summary
    Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion. Involved in negative regulation of cell population proliferation; negative regulation of macrophage activation; and negative regulation of neuroinflammatory response. Located in cell surface. Is active in postsynaptic density and presynaptic active zone. Is expressed in several structures, including bone; metanephros; nervous system; retina; and skin. Used to study autoimmune disease. Orthologous to human CD200 (CD200 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 82.1), whole brain E14.5 (RPKM 45.1) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd200 in Genome Data Viewer
    Location:
    16 B5; 16 29.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45202474..45229419, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45382111..45409060, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40916 Neighboring gene STARR-seq mESC enhancer starr_40917 Neighboring gene predicted gene, 30636 Neighboring gene STARR-positive B cell enhancer ABC_E7454 Neighboring gene predicted gene, 30760 Neighboring gene STARR-positive B cell enhancer mm9_chr16:45390029-45390330 Neighboring gene CD200 molecule like 1 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene ankyrin repeat domain 35 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation. Costello DA, et al. J Biol Chem, 2011 Oct 7. PMID 21835925, Free PMC Article
    2. CD200 dysfunction in neuron contributes to synaptic deficits and cognitive impairment. Feng D, et al. Biochem Biophys Res Commun, 2019 Sep 3. PMID 31277944
    3. Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance? Rosenblum MD, et al. J Invest Dermatol, 2004 Nov. PMID 15482475
    4. Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice. Yang Y, et al. Neurosci Lett, 2018 Jun 21. PMID 29729356
    5. The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon. Seeds RE, et al. Int Immunopharmacol, 2011 Jul. PMID 21281752, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brain endothelial CD200 signaling protects brain against ischemic damage.
      Title: Brain endothelial CD200 signaling protects brain against ischemic damage.
    2. Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-kappaB signaling pathway in aged mice.
      Title: Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice.
    3. Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
      Title: Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
    4. The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
      Title: The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
    5. Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke.
      Title: Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke.
    6. CD200 -dependent and -independent immune-modulatory functions of neural stem cells.
      Title: CD200 -dependent and -independent immune-modulatory functions of neural stem cells.
    7. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.
      Title: CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.
    8. CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
      Title: CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
    9. The CD200 Regulates Inflammation in Mice Independently of TNF-alpha Production.
      Title: The CD200 Regulates Inflammation in Mice Independently of TNF-α Production.
    10. CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
      Title: CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
    Submit: New GeneRIF Correction See all GeneRIFs (64)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell-cell adhesion mediator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding involved in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterotypic cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of macrophage migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of matrix metallopeptidase secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuroinflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuroinflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of arginase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-glutamine gamma-glutamyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    OX-2 membrane glycoprotein
    Names
    CD200 antigen
    MRC OX-2 antigen
    antigen identified by monoclonal antibody MRC OX-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358443.1 → NP_001345372.1  OX-2 membrane glycoprotein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC117686, AC117783
      Conserved Domains (2) summary
      pfam00047
      Location:69 → 155
      ig; Immunoglobulin domain
      cl11960
      Location:1 → 64
      Ig; Immunoglobulin domain

    2. NM_010818.3 → NP_034948.3  OX-2 membrane glycoprotein isoform 1 precursor

      See identical proteins and their annotated locations for NP_034948.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC054759, CN665640
      Consensus CDS
      CCDS49860.1
      UniProtKB/Swiss-Prot
      O54816, O54901, Q9JHD5
      UniProtKB/TrEMBL
      Q80VX2
      Related
      ENSMUSP00000130518.2, ENSMUST00000163230.8
      Conserved Domains (2) summary
      cd05846
      Location:44 → 140
      Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
      pfam00047
      Location:143 → 229
      ig; Immunoglobulin domain

    RNA

    1. NR_189160.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117686, AC117783

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45202474..45229419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316890.3 → XP_017172379.1  OX-2 membrane glycoprotein isoform X1

      Conserved Domains (1) summary
      pfam00047
      Location:47 → 133
      ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54901.1 GenPept UniProtKB/Swiss-Prot:O54901

    Gene LinkOut

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