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    strl-1 [ Caenorhabditis elegans ]

    Gene ID: 172846, updated on 22-Aug-2024

    Summary

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    Official Symbol
    strl-1
    Primary source
    WormBase:WBGene00009940
    Locus tag
    CELE_F52F12.7
    See related
    AllianceGenome:WB:WBGene00009940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipid binding activity. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (9928993..9930885)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Methyltranfer_dom domain-containing protein Neighboring gene BAR domain-containing protein Neighboring gene MRG domain-containing protein Neighboring gene Dysbindin protein homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions. Chen Y, et al. Reprod Toxicol, 2019 Dec. PMID 31445225, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle tethering to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    START domain-containing protein;Steroidogenic acute regulatory-like protein 1
    NP_001251250.1
    • Confirmed by transcript evidence
    NP_001251251.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9928993..9930885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264321.3 → NP_001251250.1  Steroidogenic acute regulatory-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17883
      Conserved Domains (1) summary
      pfam01852
      Location:52 → 255
      START; START domain

    2. NM_001264322.2 → NP_001251251.1  START domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUI0
      Conserved Domains (1) summary
      pfam01852
      Location:34 → 237
      START; START domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17883.2

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