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    nra-2 Nicalin [ Caenorhabditis elegans ]

    Gene ID: 172803, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nra-2
    Official Full Name
    Nicalin
    Primary source
    WormBase:WBGene00011488
    Locus tag
    CELE_T05F1.1
    See related
    AllianceGenome:WB:WBGene00011488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in protein-containing complex assembly and regulation of protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in body wall musculature; egg-laying apparatus; excretory canal; neurons; and pharyngeal muscle cell. Orthologous to human NCLN (nicalin). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nra-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9620227..9622377)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative histone-binding protein rba-1 Neighboring gene putative histone-binding protein lin-53 Neighboring gene F-box associated domain-containing protein Neighboring gene Small ribosomal subunit protein eS19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels. Kamat S, et al. J Biol Chem, 2014 Apr 25. PMID 24567339, Free PMC Article
    2. An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse. Almedom RB, et al. EMBO J, 2009 Sep 2. PMID 19609303, Free PMC Article
    3. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    4. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nicalin
    NP_001122514.1
    • Confirmed by transcript evidence
    NP_492553.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9620227..9622377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129042.4 → NP_001122514.1  Nicalin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122514.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5JYX8, O18033
      Conserved Domains (1) summary
      cd03882
      Location:121 → 430
      M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein

    2. NM_060152.5 → NP_492553.1  Nicalin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18033
      Conserved Domains (1) summary
      cd03882
      Location:124 → 424
      M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5JYX8.1

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