psma6a proteasome 20S subunit alpha 6a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psma6aprovided by ZNC
Official Full Name: proteasome 20S subunit alpha 6aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020326-1
See related: Ensembl:ENSDARG00000019398 AllianceGenome:ZFIN:ZDB-GENE-020326-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, alpha-subunit complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (12955390..12966938, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (12801324..12812872, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fj49c02.y1 (e-PCR)
- UniSTS:199445

D16S3125 (e-PCR), detects polymorphism
- UniSTS:74874

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome subunit alpha type-6a

Names: proteasome (prosome, macropain) subunit, alpha type, 6a; proteasome subunit alpha 6a

NP_001296973.1

EC 3.4.25.1

NP_705941.2

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310044.1 → NP_001296973.1 proteasome subunit alpha type-6a isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in the use of a downstream in-frame start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

BX649530, EH482391, EH537517

UniProtKB/TrEMBL

A0A8M1P7V6

Related

ENSDART00000145144.2

Conserved Domains (1) summary

cl00467
Location:1 → 141

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
NM_153655.2 → NP_705941.2 proteasome subunit alpha type-6a isoform 1

See identical proteins and their annotated locations for NP_705941.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BX649530, EH482391, EH537517

UniProtKB/TrEMBL

B2GQQ0, Q7SXN6

Related

ENSDARP00000006320.6, ENSDART00000022874.8

Conserved Domains (2) summary

PRK03996
Location:6 → 239

PRK03996; proteasome subunit alpha; Provisional

cd03754
Location:8 → 220

proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...