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    Klc3 kinesin light chain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171549, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Klc3provided by RGD
    Official Full Name
    kinesin light chain 3provided by RGD
    Primary source
    RGD:621432
    See related
    EnsemblRapid:ENSRNOG00000018101 AllianceGenome:RGD:621432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Klct
    Summary
    Predicted to enable kinesin binding activity and microtubule binding activity. Predicted to be involved in sperm mitochondrial sheath assembly. Predicted to act upstream of or within axo-dendritic transport. Located in mitochondrion. Orthologous to human KLC3 (kinesin light chain 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 82.6), Thymus (RPKM 52.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klc3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88173842..88183806, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79045842..79055809, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80306074..80315886, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 13 like Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene microRNA 343 Neighboring gene creatine kinase, M-type Neighboring gene microtubule affinity regulating kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat kinesin light chain 3 associates with spermatid mitochondria. Zhang Y, et al. Dev Biol, 2004 Nov 1. PMID 15464570, Free PMC Article
    2. Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. Bhullar B, et al. J Biol Chem, 2003 May 2. PMID 12594206, Free PMC Article
    3. Kinesin light-chain KLC3 expression in testis is restricted to spermatids. Junco A, et al. Biol Reprod, 2001 May. PMID 11319135, Free PMC Article
    4. The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Yang J, et al. Exp Cell Res, 2005 Oct 1. PMID 16018997
    5. Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. Muresan Z, et al. J Cell Biol, 2005 Nov 21. PMID 16301330, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Can associate with mitochondria.
      Title: Rat kinesin light chain 3 associates with spermatid mitochondria.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114264

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axo-dendritic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm mitochondrial sheath assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm mitochondrial sheath assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary rootlet ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin light chain 3
    Names
    kinesin light chain KLCt

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138520.2 → NP_612529.2  kinesin light chain 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q68G30, Q9ESH7
      UniProtKB/TrEMBL
      A6J8N0
      Conserved Domains (3) summary
      TIGR02168
      Location:21 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:291 → 319
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:247 → 323
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      88173842..88183806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228378.5 → XP_006228440.2  kinesin light chain 3 isoform X2

      UniProtKB/Swiss-Prot
      Q68G30, Q9ESH7
      UniProtKB/TrEMBL
      A6J8N0
      Related
      ENSRNOP00000060483.3, ENSRNOT00000068092.5
      Conserved Domains (3) summary
      TIGR02168
      Location:21 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:291 → 319
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:247 → 323
      TPR_12; Tetratricopeptide repeat

    2. XM_063277750.1 → XP_063133820.1  kinesin light chain 3 isoform X1

      Related
      ENSRNOP00000104312.1, ENSRNOT00000123369.1

    3. XM_006228379.5 → XP_006228441.1  kinesin light chain 3 isoform X1

      Related
      ENSRNOP00000111547.1, ENSRNOT00000143655.1
      Conserved Domains (3) summary
      TIGR02168
      Location:21 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:291 → 319
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:247 → 323
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68G30.1 GenPept UniProtKB/Swiss-Prot:Q68G30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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