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    Arhgap4 Rho GTPase activating protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 171207, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arhgap4provided by MGI
    Official Full Name
    Rho GTPase activating protein 4provided by MGI
    Primary source
    MGI:MGI:2159577
    See related
    Ensembl:ENSMUSG00000031389 AllianceGenome:MGI:2159577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    c1; Rgc1; mKIAA0131; A130009C12Rik; A530015A20Rik
    Summary
    Predicted to enable GTPase activator activity and identical protein binding activity. Predicted to be involved in negative regulation of axon extension and negative regulation of fibroblast migration. Predicted to be located in several cellular components, including growth cone; microtubule; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human ARHGAP4 (Rho GTPase activating protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 79.1), spleen adult (RPKM 57.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap4 in Genome Data Viewer
    Location:
    X A7.3; X 37.45 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72937958..72954945, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73894352..73911345, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_47357 Neighboring gene predicted gene, 23615 Neighboring gene STARR-seq mESC enhancer starr_47358 Neighboring gene STARR-seq mESC enhancer starr_47359 Neighboring gene L1 cell adhesion molecule Neighboring gene arginine vasopressin receptor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:71157031-71157252 Neighboring gene STARR-seq mESC enhancer starr_47360 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. p115 Rho GTPase activating protein interacts with MEKK1. Christerson LB, et al. J Cell Physiol, 2002 Aug. PMID 12115726
    2. Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules. Foletta VC, et al. Brain Res Mol Brain Res, 2002 Oct 30. PMID 12414125
    3. PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. Bai Y, et al. J Biol Chem, 2011 Dec 9. PMID 22009749, Free PMC Article
    4. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Chen XW, et al. Mol Biol Cell, 2011 Jan 1. PMID 21148297, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation
      Title: PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
    2. The p115 Rho GAP binds to MEKK1 in vitro and in intact cells. Expression of p115 Rho GAP reduces MEKK1-induced signaling to AP-1.
      Title: p115 Rho GTPase activating protein interacts with MEKK1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC124367, MGC124368

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 4
    Names
    GTPase-activating protein p115

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162423.1 → NP_001155895.1  rho GTPase-activating protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AK028789, AK040687, AL672002
      Consensus CDS
      CCDS53101.1
      UniProtKB/TrEMBL
      B1AUY2, Q32MS4
      Related
      ENSMUSP00000110046.2, ENSMUST00000114404.8
      Conserved Domains (3) summary
      cd07656
      Location:26 → 292
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:514 → 690
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:748 → 802
      SH3; Src Homology 3 domain superfamily

    2. NM_001162424.1 → NP_001155896.1  rho GTPase-activating protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001155896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AK028789, AK040687, AL672002
      Consensus CDS
      CCDS53100.1
      UniProtKB/TrEMBL
      B1AUX5, Q8VHL8
      Related
      ENSMUSP00000110049.3, ENSMUST00000114407.9
      Conserved Domains (3) summary
      cd07656
      Location:26 → 271
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:493 → 680
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:738 → 792
      SH3; Src Homology 3 domain superfamily

    3. NM_138630.2 → NP_619536.2  rho GTPase-activating protein 4 isoform 1

      See identical proteins and their annotated locations for NP_619536.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK028789, AK040687, AL672002
      Consensus CDS
      CCDS41014.1
      UniProtKB/TrEMBL
      Q80Z68, Q8VHL8
      Related
      ENSMUSP00000067477.7, ENSMUST00000064376.13
      Conserved Domains (3) summary
      cd07656
      Location:26 → 292
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:514 → 701
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:759 → 813
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72937958..72954945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247535.4 → XP_011245837.1  rho GTPase-activating protein 4 isoform X6

      UniProtKB/TrEMBL
      Q3TE27
      Related
      ENSMUSP00000110048.3, ENSMUST00000114406.9
      Conserved Domains (4) summary
      COG1196
      Location:141 → 377
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl02570
      Location:401 → 588
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:30 → 242
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:652 → 706
      SH3; Src Homology 3 domain superfamily

    2. XM_011247531.4 → XP_011245833.1  rho GTPase-activating protein 4 isoform X2

      UniProtKB/TrEMBL
      Q8VHL8
      Conserved Domains (3) summary
      cd07656
      Location:26 → 292
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:514 → 701
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:765 → 819
      SH3; Src Homology 3 domain superfamily

    3. XM_011247533.4 → XP_011245835.1  rho GTPase-activating protein 4 isoform X4

      UniProtKB/TrEMBL
      Q8VHL8
      Conserved Domains (3) summary
      cd07656
      Location:30 → 275
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:497 → 684
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:748 → 802
      SH3; Src Homology 3 domain superfamily

    4. XM_011247530.3 → XP_011245832.1  rho GTPase-activating protein 4 isoform X1

      UniProtKB/TrEMBL
      Q8VHL8
      Conserved Domains (3) summary
      cd07656
      Location:30 → 296
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:518 → 705
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:769 → 823
      SH3; Src Homology 3 domain superfamily

    5. XM_011247532.4 → XP_011245834.1  rho GTPase-activating protein 4 isoform X3

      UniProtKB/TrEMBL
      Q8VHL8
      Conserved Domains (3) summary
      cd07656
      Location:30 → 296
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:518 → 705
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:763 → 817
      SH3; Src Homology 3 domain superfamily

    6. XM_011247534.4 → XP_011245836.1  rho GTPase-activating protein 4 isoform X5

      UniProtKB/TrEMBL
      Q8VHL8
      Conserved Domains (3) summary
      cd07656
      Location:3 → 269
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:491 → 678
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:742 → 796
      SH3; Src Homology 3 domain superfamily

    7. XM_011247536.4 → XP_011245838.1  rho GTPase-activating protein 4 isoform X7

      UniProtKB/TrEMBL
      Q8BM00
      Conserved Domains (2) summary
      cl02570
      Location:165 → 352
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:416 → 470
      SH3; Src Homology 3 domain superfamily

    8. XM_011247537.3 → XP_011245839.1  rho GTPase-activating protein 4 isoform X8

      UniProtKB/TrEMBL
      Q8BM00
      Conserved Domains (2) summary
      cl02570
      Location:152 → 339
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:403 → 457
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
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