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    Atp6v0c ATPase H+ transporting V0 subunit C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170667, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atp6v0cprovided by RGD
    Official Full Name
    ATPase H+ transporting V0 subunit Cprovided by RGD
    Primary source
    RGD:621394
    See related
    EnsemblRapid:ENSRNOG00000006542 AllianceGenome:RGD:621394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp6c; Atp6l
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of autophagic cell death and positive regulation of ERK1 and ERK2 cascade. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 334.0), Brain (RPKM 332.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp6v0c in Genome Data Viewer
    Location:
    10q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13700764..13707147, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13196204..13202580, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13537031..13543407, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 3-phosphoinositide dependent protein kinase-1 Neighboring gene amidohydrolase domain containing 2 Neighboring gene TBC1 domain family, member 24 Neighboring gene netrin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle Acidification. Rama S, et al. Mol Neurobiol, 2019 May. PMID 30155790
    2. Protective effects of vacuolar H+ -ATPase c on hydrogen peroxide-induced cell death in C6 glioma cells. Byun YJ, et al. Neurosci Lett, 2007 Oct 2. PMID 17845832
    3. Molecular cloning of a rat liver cDNA encoding the 16 kDa subunit of vacuolar H(+)-ATPases: organellar and tissue distribution of 16 kDa proteolipids. Nezu J, et al. J Biochem, 1992 Aug. PMID 1400263
    4. PFKFB2 Promoter Hypomethylation as Recurrence Predictive Marker in Well-Differentiated Thyroid Carcinomas. Camargo Barros-Filho M, et al. Int J Mol Sci, 2019 Mar 16. PMID 30884810, Free PMC Article
    5. The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex. Galli T, et al. J Biol Chem, 1996 Jan 26. PMID 8567678

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. V-ATPase c-subunit V0c is a key element in modulating neurotransmission and that its specific inactivation rapidly inhibited neurotransmission.
      Title: Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle Acidification.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting V-type ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase 16 kDa proteolipid subunit c
    Names
    ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit C
    ATPase, H+ transporting, lysosomal 1
    ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
    ATPase, H+ transporting, lysosomal V0 subunit C
    V-ATPase 16 kDa proteolipid subunit
    V-ATPase 16 kDa proteolipid subunit c
    V-type proton ATPase 16 kDa proteolipid subunit
    vacuolar proton pump 16 kDa proteolipid subunit
    vacuolar proton pump 16 kDa proteolipid subunit c
    NP_570836.1
    XP_006245960.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130823.4 → NP_570836.1  V-type proton ATPase 16 kDa proteolipid subunit c

      See identical proteins and their annotated locations for NP_570836.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63081
      UniProtKB/TrEMBL
      A0A8L2Q4M1, A6HCQ5
      Conserved Domains (2) summary
      TIGR01100
      Location:13 → 118
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:86 → 153
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13700764..13707147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245898.2 → XP_006245960.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform X1

      See identical proteins and their annotated locations for XP_006245960.1

      UniProtKB/Swiss-Prot
      P63081
      UniProtKB/TrEMBL
      A0A8L2Q4M1, A6HCQ5
      Related
      ENSRNOP00000008736.5, ENSRNOT00000008736.8
      Conserved Domains (2) summary
      TIGR01100
      Location:13 → 118
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:86 → 153
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63081.1 GenPept UniProtKB/Swiss-Prot:P63081

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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