Inhba inhibin beta-A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inhbaprovided by MGI
Official Full Name: inhibin beta-Aprovided by MGI
Primary source: MGI:MGI:96570
See related: Ensembl:ENSMUSG00000041324 AllianceGenome:MGI:96570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. [provided by RefSeq, Aug 2016]
Expression: Biased expression in ovary adult (RPKM 8.8), liver E18 (RPKM 1.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 5.85 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (16178841..16206194)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (16004256..16031609)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy.
Title: Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy.
Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis.
Title: Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis.
Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling.
Title: Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling.
Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice.
Title: Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice.
Testicular immune cell populations and macrophage polarisation in adult male mice and the influence of altered activin A levels.
Title: Testicular immune cell populations and macrophage polarisation in adult male mice and the influence of altered activin A levels.
The TGF-beta superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation.
Title: The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation.
Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A.
Title: Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A.
Activin A Determines Steroid Levels and Composition in the Fetal Testis.
Title: Activin A Determines Steroid Levels and Composition in the Fetal Testis.
The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.
Title: The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.
Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds.
Title: Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:496691 (e-PCR)
- UniSTS:496691

Inhba (e-PCR), detects polymorphism
- UniSTS:496691

Inhba (e-PCR), detects polymorphism
- UniSTS:480346

Inhba (e-PCR), detects polymorphism
- UniSTS:143588

UniSTS:143589 (e-PCR)
- UniSTS:143589

Inhba (e-PCR), detects polymorphism
- UniSTS:143589

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables type II activin receptor binding	IEA Inferred from Electronic Annotation more info
enables type II activin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GABAergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Sertoli cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within androgen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within androst-4-ene-3,17-dione biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in cardiac fibroblast cell development	IEA Inferred from Electronic Annotation more info
involved_in cardiac fibroblast cell development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cholesterol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to follicle-stimulating hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxygen-glucose deprivation	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in eyelid development in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of hair follicle development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hemoglobin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesoderm formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mesodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of hair follicle development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info
involved_in progesterone secretion	ISO Inferred from Sequence Orthology more info
involved_in progesterone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of follicle-stimulating hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to aldosterone	IEA Inferred from Electronic Annotation more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within steroid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striatal medium spiny neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in striatal medium spiny neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within testosterone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of activin A complex	ISO Inferred from Sequence Orthology more info
part_of activin A complex	ISS Inferred from Sequence or Structural Similarity more info
part_of enzyme activator complex	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of inhibin A complex	ISO Inferred from Sequence Orthology more info
part_of inhibin A complex	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inhibin beta A chain

Names: activin A; activin beta-A chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008380.2 → NP_032406.1 inhibin beta A chain preproprotein

See identical proteins and their annotated locations for NP_032406.1

Status: REVIEWED

Source sequence(s)

AC154742, AC161586, AK134991, BP759054

Consensus CDS

CCDS26251.1

UniProtKB/Swiss-Prot

Q04998

UniProtKB/TrEMBL

Q3UY39, Q4FJM4

Related

ENSMUSP00000047894.7, ENSMUST00000042603.14

Conserved Domains (2) summary

pfam00688
Location:56 → 291

TGFb_propeptide; TGF-beta propeptide

cd19404
Location:317 → 424

TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

16178841..16206194

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244285.3 → XP_011242587.1 inhibin beta A chain isoform X1

See identical proteins and their annotated locations for XP_011242587.1

UniProtKB/Swiss-Prot

Q04998

UniProtKB/TrEMBL

Q3UY39, Q4FJM4

Related

ENSMUSP00000132085.2, ENSMUST00000164993.2

Conserved Domains (2) summary

pfam00688
Location:56 → 291

TGFb_propeptide; TGF-beta propeptide

cd19404
Location:317 → 424

TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
XM_006516559.4 → XP_006516622.1 inhibin beta A chain isoform X1

See identical proteins and their annotated locations for XP_006516622.1

UniProtKB/Swiss-Prot

Q04998

UniProtKB/TrEMBL

Q3UY39, Q4FJM4

Conserved Domains (2) summary

pfam00688
Location:56 → 291

TGFb_propeptide; TGF-beta propeptide

cd19404
Location:317 → 424

TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins