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    D12L secreted complement-binding protein [ Variola virus ]

    Gene ID: 1486392, updated on 18-Aug-2023

    Summary

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    Gene symbol
    D12L
    Gene description
    secreted complement-binding protein
    Locus tag
    VARVgp012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Variola virus (strain: India-1967, ssp. major, isolate: Ind3)
    Lineage
    Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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    Genomic context

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    Sequence:
    NC_001611.1 (11600..12391, complement)

    NC_001611.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001611.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the nucleotide sequence of 23.8 kbp from the left terminus of the genome of variola major virus strain India-1967. Shchelkunov SN, et al. Virus Res, 1996 Feb. PMID 8725113
    2. Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms. Shchelkunov SN, et al. FEBS Lett, 1993 Mar 15. PMID 8384129
    3. Analysis of the nucleotide sequence of 53 kbp from the right terminus of the genome of variola major virus strain India-1967. Shchelkunov SN, et al. Virus Res, 1994 Dec. PMID 7856312
    4. Two types of deletions in orthopoxvirus genomes. Shchelkunov SN, et al. Virus Genes, 1995 Feb. PMID 7597802

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    secreted complement-binding protein
    NP_042056.1
    • secreted complement-binding protein; binds host complement components C3b and C4b to modulate the host inflammatory response; blocks both classical and alternative pathways of complement activity; similar to Vaccinia virus Copenhagen C3L; the poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001611.1 Reference assembly

      Range
      11600..12391 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_042056.1 secreted complement-binding protein [Variola virus]

      See identical proteins and their annotated locations for NP_042056.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q07033, Q0NCW0, Q0NGC7, Q76U65, Q89859
      Conserved Domains (3) summary
      cd00033
      Location:148 → 202
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:1 → 263
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:21 → 79
      Sushi; Sushi repeat (SCR repeat)
    Nucleotide Protein
    Heading Accession and Version

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