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    LAYN layilin [ Homo sapiens (human) ]

    Gene ID: 143903, updated on 12-Nov-2024

    Summary

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    Official Symbol
    LAYNprovided by HGNC
    Official Full Name
    layilinprovided by HGNC
    Primary source
    HGNC:HGNC:29471
    See related
    Ensembl:ENSG00000204381 MIM:618843; AllianceGenome:HGNC:29471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables hyaluronic acid binding activity. Located in focal adhesion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary (RPKM 7.0), thyroid (RPKM 6.2) and 20 other tissues See more
    Orthologs
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    Genomic context

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    See LAYN in Genome Data Viewer
    Location:
    11q23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111540280..111561745)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111550425..111571891)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111411005..111432470)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BTG anti-proliferation factor 4 Neighboring gene MIR34B and MIR34C host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111410548-111411227 Neighboring gene microRNA 34c Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:111424938-111426137 Neighboring gene Sharpr-MPRA regulatory region 3081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:111435687-111436190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3899 Neighboring gene salt inducible kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111563346-111563859 Neighboring gene RN7SK pseudogene 273 Neighboring gene protein phosphatase 2 scaffold subunit Abeta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111594031-111594566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111603371-111604187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:111605768-111606404 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:111636139-111637042

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status. Liu C, et al. Immunol Invest, 2023 Nov. PMID 37642473
    2. Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer. Jiawen W, et al. J Cancer Res Clin Oncol, 2023 Oct. PMID 37335337
    3. ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis. Cao L, et al. Biomed Res Int, 2022. PMID 36398067, Free PMC Article
    4. Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins. Arito M, et al. BMC Mol Cell Biol, 2024 Oct 25. PMID 39455917, Free PMC Article
    5. LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers. Pan JH, et al. Front Immunol, 2019. PMID 30761122, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins.
      Title: Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins.
    2. Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status.
      Title: Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status.
    3. Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer.
      Title: Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer.
    4. ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis.
      Title: ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis.
    5. Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells.
      Title: Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells.
    6. Layilin augments integrin activation to promote antitumor immunity.
      Title: Layilin augments integrin activation to promote antitumor immunity.
    7. increased LAYN expression correlates with poor prognosis and increased immune infiltration levels in CD8+ T cells, CD4+ T cells, macrophages, neutrophils and DCs of multiple cancers, especially in colon and gastric cancers.
      Title: LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers.
    8. Renal biopsy samples from patients with glomerulonephritis showed high expression of LAYN in tubular epithelial cells.
      Title: Roles of layilin in TNF-α-induced epithelial-mesenchymal transformation of renal tubular epithelial cells.
    9. results indicate that LAYN would be involved in the enhancement of inflammation and degradation of cartilage in joint diseases such as RA and OA
      Title: Secretion of inflammatory factors from chondrocytes by layilin signaling.
    10. Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin.
      Title: Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ30977, FLJ31092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hyaluronic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hyaluronic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion HDA PubMed 
    NOT located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    layilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258390.2 → NP_001245319.1  layilin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001245319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK055539, AK296231, AY358554, DA608521
      Consensus CDS
      CCDS58178.1
      UniProtKB/Swiss-Prot
      A6NJB0, B4DJU0, Q6UX15, Q8TAY8, Q96NC5, Q96NF3
      UniProtKB/TrEMBL
      B4DP26
      Related
      ENSP00000364765.3, ENST00000375615.7
      Conserved Domains (1) summary
      cd03595
      Location:38 → 186
      CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

    2. NM_001258391.2 → NP_001245320.1  layilin isoform 3

      See identical proteins and their annotated locations for NP_001245320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two internal exons and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK055539, AK296231, DA608521, DB006476
      Consensus CDS
      CCDS58179.1
      UniProtKB/Swiss-Prot
      Q6UX15
      Related
      ENSP00000392942.2, ENST00000436913.6

    3. NM_001318799.1 → NP_001305728.1  layilin isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK055539, AP002008, DC398135
      UniProtKB/TrEMBL
      B4DDS5
      Conserved Domains (1) summary
      cl02432
      Location:1 → 34
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    4. NM_178834.5 → NP_849156.1  layilin isoform 2 precursor

      See identical proteins and their annotated locations for NP_849156.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK055539, AK296231, DA608521
      Consensus CDS
      CCDS31676.1
      UniProtKB/TrEMBL
      B4DP26
      Related
      ENSP00000364764.2, ENST00000375614.7
      Conserved Domains (1) summary
      cd03595
      Location:30 → 178
      CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      111540280..111561745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718769.5 → XP_006718832.1  layilin isoform X1

      See identical proteins and their annotated locations for XP_006718832.1

      UniProtKB/TrEMBL
      B4DDS5
      Conserved Domains (1) summary
      cl02432
      Location:1 → 34
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      111550425..111571891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367767.1 → XP_054223742.1  layilin isoform X1

      UniProtKB/TrEMBL
      B4DDS5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UX15.1 GenPept UniProtKB/Swiss-Prot:Q6UX15

    Gene LinkOut

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