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    Fgf12 fibroblast growth factor 12 [ Mus musculus (house mouse) ]

    Gene ID: 14167, updated on 29-Oct-2024

    Summary

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    Official Symbol
    Fgf12provided by MGI
    Official Full Name
    fibroblast growth factor 12provided by MGI
    Primary source
    MGI:MGI:109183
    See related
    Ensembl:ENSMUSG00000022523 AllianceGenome:MGI:109183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fhf1; FHF-1; Fgf1a; FGF-12; B230343J05Rik
    Summary
    Predicted to enable heparin binding activity; sodium channel regulator activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including adult locomotory behavior; neuromuscular process; and positive regulation of sodium ion transport. Predicted to be located in synapse. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; limb; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 47. Orthologous to human FGF12 (fibroblast growth factor 12). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 10.5), cortex adult (RPKM 7.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fgf12 in Genome Data Viewer
    Location:
    16 B2; 16 19.38 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (27976535..28571995, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (28157783..28753243, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40500 Neighboring gene zinc finger protein 106 pseudogene Neighboring gene predicted gene 10823 Neighboring gene STARR-seq mESC enhancer starr_40501 Neighboring gene STARR-seq mESC enhancer starr_40502 Neighboring gene STARR-seq mESC enhancer starr_40503 Neighboring gene STARR-seq mESC enhancer starr_40504 Neighboring gene STARR-seq mESC enhancer starr_40505 Neighboring gene STARR-seq mESC enhancer starr_40506 Neighboring gene predicted gene, 52250 Neighboring gene predicted gene, 53944 Neighboring gene STARR-seq mESC enhancer starr_40507 Neighboring gene STARR-seq mESC enhancer starr_40509 Neighboring gene predicted gene, 46548 Neighboring gene microRNA 690 Neighboring gene STARR-seq mESC enhancer starr_40512 Neighboring gene STARR-seq mESC enhancer starr_40513 Neighboring gene STARR-seq mESC enhancer starr_40515 Neighboring gene STARR-seq mESC enhancer starr_40516 Neighboring gene predicted gene, 20018 Neighboring gene Mab-21 domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phenotyping of FGF12A(V52H) mutation in mouse implies a complex FGF12 network. Huang J, et al. Neurobiol Dis, 2024 Oct 1. PMID 39142611
    2. Assignment of Fgf12 to mouse chromosome bands 16B1-->B3 by in situ hybridization. Hartung H, et al. Cytogenet Cell Genet, 1997. PMID 9186519
    3. Fibroblast growth factor homologous factor 1 (FHF1) is expressed in a subpopulation of calcitonin gene-related peptide-positive nociceptive neurons in the murine dorsal root ganglia. Hubert T, et al. J Comp Neurol, 2008 Apr 1. PMID 18220257
    4. Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function. Hanada Y, et al. Sci Rep, 2018 Jul 31. PMID 30065296, Free PMC Article
    5. FGF12 (Fibroblast Growth Factor 12) Inhibits Vascular Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension. Yeo Y, et al. Hypertension, 2020 Dec. PMID 33100045

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phenotyping of FGF12A[V52H] mutation in mouse implies a complex FGF12 network.
      Title: Phenotyping of FGF12A(V52H) mutation in mouse implies a complex FGF12 network.
    2. Macrophage-specific FGF12 promotes liver fibrosis progression in mice.
      Title: Macrophage-specific FGF12 promotes liver fibrosis progression in mice.
    3. Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12).
      Title: Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12).
    4. Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress.
      Title: Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress.
    5. FGF12 (Fibroblast Growth Factor 12) Inhibits Vascular Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension.
      Title: FGF12 (Fibroblast Growth Factor 12) Inhibits Vascular Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension.
    6. FGF12 is necessary for normal auditory and equilibrium function.
      Title: Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function.
    7. FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation.
      Title: Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate.
    8. FGF21 does not appear necessary for exercise-induced systemic and hepatic mitochondrial adaptations, but the increased adiposity, hyperinsulinemia, and impairments in hepatic mitochondrial function induced by FGF21 deficiency can be partially rescued by daily wheel running exercise.
      Title: Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations.
    9. results argue strongly against the possibility that FHF1 has a modulatory effect on the Na(v)1.9 sodium channel isoform in cRet+/IB4+ neurons, but FHF1 could play a role in a distinct subset of TrkA+/CGRP+ nociceptors.
      Title: Fibroblast growth factor homologous factor 1 (FHF1) is expressed in a subpopulation of calcitonin gene-related peptide-positive nociceptive neurons in the murine dorsal root ganglia.
    10. x-ray crystal structure of FHF1b
      Title: Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chemical synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromuscular process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuronal action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of voltage-gated sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor 12
    Names
    fibroblast growth factor 1a
    fibroblast growth factor homologous factor 1
    myocyte-activating factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276419.2 → NP_001263348.1  fibroblast growth factor 12 isoform c

      See identical proteins and their annotated locations for NP_001263348.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure, differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform c which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC154619, AC154656, AC154663, AK011712, AK034150, AK034335, AK046130, BY477982
      UniProtKB/TrEMBL
      A0A338P764
      Conserved Domains (1) summary
      pfam00167
      Location:38 → 162
      FGF; Fibroblast growth factor

    2. NM_001276420.1 → NP_001263349.1  fibroblast growth factor 12 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' exon structure and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform d which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC154663, AK018774, AK148215, BP768136
      Consensus CDS
      CCDS88908.1
      UniProtKB/TrEMBL
      A0A338P752, Q3UFZ2
      Related
      ENSMUSP00000156274.2, ENSMUST00000231717.2
      Conserved Domains (1) summary
      cl00060
      Location:76 → 105
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    3. NM_001357064.1 → NP_001343993.1  fibroblast growth factor 12 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC154619, AC154656, AC154663
      Conserved Domains (1) summary
      pfam00167
      Location:1 → 112
      FGF; Fibroblast growth factor

    4. NM_010199.4 → NP_034329.1  fibroblast growth factor 12 isoform b

      See identical proteins and their annotated locations for NP_034329.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure, differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform b which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC154619, AK034150, AK034335, AK046130, BB611389, BY477982, CX239635
      Consensus CDS
      CCDS88909.1
      UniProtKB/Swiss-Prot
      P61329
      Related
      ENSMUSP00000155924.2, ENSMUST00000232352.2
      Conserved Domains (1) summary
      pfam00167
      Location:12 → 136
      FGF; Fibroblast growth factor

    5. NM_183064.5 → NP_898887.1  fibroblast growth factor 12 isoform a

      See identical proteins and their annotated locations for NP_898887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC154619, AC154663, AK034150, AK034335, AK046130, AK148215, BY477982
      Consensus CDS
      CCDS28092.1
      UniProtKB/Swiss-Prot
      P61329, Q924B4
      UniProtKB/TrEMBL
      A0A7U3JW65
      Related
      ENSMUSP00000097601.2, ENSMUST00000100024.3
      Conserved Domains (1) summary
      pfam00167
      Location:74 → 198
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      27976535..28571995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61329.1 GenPept UniProtKB/Swiss-Prot:P61329

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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