Emp2 epithelial membrane protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Emp2provided by MGI
Official Full Name: epithelial membrane protein 2provided by MGI
Primary source: MGI:MGI:1098726
See related: Ensembl:ENSMUSG00000022505 AllianceGenome:MGI:1098726
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: XMP
Summary: Enables integrin binding activity. Involved in several processes, including early endosome to late endosome transport; embryonic process involved in female pregnancy; and protein localization to cell surface. Acts upstream of or within positive regulation of integrin-mediated signaling pathway. Located in Golgi apparatus; apical plasma membrane; and cell surface. Colocalizes with cytoplasmic vesicle; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; endometrium; medulla oblongata lateral wall; respiratory system; and sensory organ. Used to study placental insufficiency. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 388.0), bladder adult (RPKM 33.5) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 5.54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (10099613..10131832, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (10281749..10313968, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface.
Title: Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface.
EMP2-dependent membrane organization ensures proper display on Alveolar epithelial type 1 (AT1) cells of a suite of proteins required to instruct paracellular neutrophil traffic into the alveolus.
Title: Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace.
Emp2 was disrupted in mouse embryonic stem cells using the CRISPR/Cas9 technology. This study discovered that loss of Emp2 compromised the differentiation of the cells into functional cardiomyocytes.
Title: Loss of Emp2 compromises cardiogenic differentiation in mouse embryonic stem cells.
the role of EMP2 in the pathogenesis of GBM a
Title: Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma.
To detect EMP2 in tumors, a recombinant human anti-EMP2 minibody (scFv-hinge-C(H)3 dimer; 80 kDa) was designed to recognize a common epitope in mice and humans and characterized.
Title: Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments.
Targeting of EMP2 to specific locations under the influence of these steroid hormones may be important for integrating the molecular responses required for implantation competence.
Title: Steroid hormone regulation of EMP2 expression and localization in the endometrium.
EMP2 regulates caveolin-1 transcription and more substantially its protein levels.
Title: The tetraspan protein EMP2 regulates expression of caveolin-1.
This protein is expressed in discrete anatomical regions of the eye.
Title: Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye.
EMP2 induces alphavbeta3 surface expression.
Title: Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium.
Knockdown of Emp2 inhibits implantation in the mouse.
Title: Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin-mediated cell contraction	ISO Inferred from Sequence Orthology more info
involved_in actin-mediated cell contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in bleb assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in caveola assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in early endosome to late endosome transport	IDA Inferred from Direct Assay more info	PubMed
involved_in embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in embryonic process involved in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane raft assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in natural killer cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane raft assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in regulation of glomerular filtration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
NOT colocalizes_with caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: epithelial membrane protein 2

Names: EMP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.