Eef2k eukaryotic elongation factor-2 kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef2kprovided by MGI
Official Full Name: eukaryotic elongation factor-2 kinaseprovided by MGI
Primary source: MGI:MGI:1195261
See related: Ensembl:ENSMUSG00000035064 AllianceGenome:MGI:1195261
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: eEF-2K
Summary: Enables calmodulin binding activity and elongation factor-2 kinase activity. Involved in regulation of protein autophosphorylation. Predicted to be located in dendritic spine. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in liver; lung; nervous system; and olfactory epithelium. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 19.4), colon adult (RPKM 10.7) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 F2; 7 64.95 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (120442080..120506441)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (120842642..120907219)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
Title: Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
Control of CD4[+] T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.
Title: Control of CD4(+) T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.
Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24[Bst] Mouse.
Title: Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24(Bst) Mouse.
eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.
Title: eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
Title: miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
[Effects of GSK3beta/eEF2K signaling pathway on pulmonary fibrosis in mice].
Title: [Effects of GSK3β/eEF2K signaling pathway on pulmonary fibrosis in mice].
Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
Title: Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells.
Title: Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells.
Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.
Title: Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.
Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Title: Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

General gene information

Go to the top of the page Help

Markers

C86191 (e-PCR)
- UniSTS:208192

RH127278 (e-PCR)
- UniSTS:209814

fl05f06.x1 (e-PCR)
- UniSTS:201902

Eef2k (e-PCR), detects polymorphism
- UniSTS:527326

NoName (e-PCR)
- UniSTS:235770

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables elongation factor-2 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables elongation factor-2 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables elongation factor-2 kinase activity	ISO Inferred from Sequence Orthology more info
enables translation factor activity, RNA binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to anoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in myosin II filament disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at postsynapse	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation at postsynapse	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to prolactin	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: eukaryotic elongation factor 2 kinase

Names: calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eukaroytic elongation factor 2 kinase

NP_001254639.1

EC 2.7.11.20

NP_001254640.1

EC 2.7.11.20

NP_001399257.1

EC 2.7.11.20

NP_001399258.1

EC 2.7.11.20

NP_001399259.1

EC 2.7.11.20

NP_001399260.1

EC 2.7.11.20

NP_001399261.1

EC 2.7.11.20

NP_001399262.1

EC 2.7.11.20

NP_001399263.1

EC 2.7.11.20

NP_031934.1

EC 2.7.11.20

XP_036008548.1

EC 2.7.11.20

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001267710.2 → NP_001254639.1 eukaryotic elongation factor 2 kinase isoform a

See identical proteins and their annotated locations for NP_001254639.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AC122214, AC122248

Consensus CDS

CCDS21796.1

UniProtKB/Swiss-Prot

O08796

UniProtKB/TrEMBL

Q7TPC7, Q8BNP6, Q8CEC8

Related

ENSMUSP00000102098.2, ENSMUST00000106489.9

Conserved Domains (3) summary

COG0790
Location:492 → 688

TPR; TPR repeat [Signal transduction mechanisms]

sd00010
Location:502 → 535

SLR; SLR repeat [structural motif]

cd16967
Location:102 → 317

Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
NM_001267711.2 → NP_001254640.1 eukaryotic elongation factor 2 kinase isoform a

See identical proteins and their annotated locations for NP_001254640.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AC122214, AC122248

Consensus CDS

CCDS21796.1

UniProtKB/Swiss-Prot

O08796

UniProtKB/TrEMBL

Q7TPC7, Q8BNP6, Q8CEC8

Related

ENSMUSP00000102097.2, ENSMUST00000106488.3

Conserved Domains (3) summary

COG0790
Location:492 → 688

TPR; TPR repeat [Signal transduction mechanisms]

sd00010
Location:502 → 535

SLR; SLR repeat [structural motif]

cd16967
Location:102 → 317

Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
NM_001412328.1 → NP_001399257.1 eukaryotic elongation factor 2 kinase isoform a

Status: VALIDATED

Source sequence(s)

AC122214, AC122248

UniProtKB/Swiss-Prot

O08796
NM_001412329.1 → NP_001399258.1 eukaryotic elongation factor 2 kinase isoform a

Status: VALIDATED

Source sequence(s)

AC122214, AC122248

UniProtKB/Swiss-Prot

O08796
NM_001412330.1 → NP_001399259.1 eukaryotic elongation factor 2 kinase isoform a

Status: VALIDATED

Source sequence(s)

AC122214, AC122248

UniProtKB/Swiss-Prot

O08796
NM_001412331.1 → NP_001399260.1 eukaryotic elongation factor 2 kinase isoform b

Status: VALIDATED

Source sequence(s)

AC122214, AC122248
NM_001412332.1 → NP_001399261.1 eukaryotic elongation factor 2 kinase isoform c

Status: VALIDATED

Source sequence(s)

AC122214, AC122248
NM_001412333.1 → NP_001399262.1 eukaryotic elongation factor 2 kinase isoform c

Status: VALIDATED

Source sequence(s)

AC122214, AC122248
NM_001412334.1 → NP_001399263.1 eukaryotic elongation factor 2 kinase isoform d

Status: VALIDATED

Source sequence(s)

AC122248
NM_007908.5 → NP_031934.1 eukaryotic elongation factor 2 kinase isoform a

See identical proteins and their annotated locations for NP_031934.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AC122214, AC122248

Consensus CDS

CCDS21796.1

UniProtKB/Swiss-Prot

O08796

UniProtKB/TrEMBL

Q7TPC7, Q8BNP6, Q8CEC8

Related

ENSMUSP00000046595.9, ENSMUST00000047875.16

Conserved Domains (3) summary

COG0790
Location:492 → 688

TPR; TPR repeat [Signal transduction mechanisms]

sd00010
Location:502 → 535

SLR; SLR repeat [structural motif]

cd16967
Location:102 → 317

Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

RNA

NR_178189.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC122214, AC122248

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

120442080..120506441

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152655.1 → XP_036008548.1 eukaryotic elongation factor 2 kinase isoform X4

UniProtKB/TrEMBL

Q8BNP6

Conserved Domains (3) summary

COG0790
Location:351 → 547

TPR; TPR repeat [Signal transduction mechanisms]

sd00010
Location:361 → 394

SLR; SLR repeat [structural motif]

cd16967
Location:1 → 176

Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase