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    Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain1 [ Mus musculus (house mouse) ]

    Gene ID: 13196, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Asap1provided by MGI
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain1provided by MGI
    Primary source
    MGI:MGI:1342335
    See related
    Ensembl:ENSMUSG00000022377 AllianceGenome:MGI:1342335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAP; s19; DEF-1; Ddef1; mKIAA1249
    Summary
    Enables GTPase activator activity and phospholipid binding activity. Involved in regulation of postsynapse organization. Acts upstream of or within negative regulation of dendritic spine development and positive regulation of membrane tubulation. Located in dendritic spine and podosome. Is active in glutamatergic synapse. Is expressed in several structures, including gonad; hemolymphoid system; limb; long bone; and nervous system. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 21.3), cortex adult (RPKM 15.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asap1 in Genome Data Viewer
    Location:
    15 D1; 15 28.55 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63958704..64254922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (64086840..64382941, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C-like, pseudogene Neighboring gene CYFIP related Rac1 interactor B Neighboring gene STARR-seq mESC enhancer starr_38847 Neighboring gene STARR-seq mESC enhancer starr_38849 Neighboring gene STARR-positive B cell enhancer ABC_E10857 Neighboring gene STARR-positive B cell enhancer ABC_E9912 Neighboring gene predicted gene, 25628 Neighboring gene STARR-positive B cell enhancer ABC_E1906 Neighboring gene predicted gene 20717 Neighboring gene STARR-seq mESC enhancer starr_38853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:64017486-64017639 Neighboring gene STARR-seq mESC enhancer starr_38854 Neighboring gene VISTA enhancer mm1716 Neighboring gene STARR-seq mESC enhancer starr_38855 Neighboring gene RIKEN cDNA 1700010G06 gene Neighboring gene STARR-seq mESC enhancer starr_38857 Neighboring gene predicted gene, 30563 Neighboring gene predicted gene, 46509

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide. Haque A, et al. Cancer Immunol Immunother, 2011 Oct. PMID 21644032, Free PMC Article
    2. DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. King FJ, et al. Mol Cell Biol, 1999 Mar. PMID 10022919, Free PMC Article
    3. The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting. Wang J, et al. EMBO J, 2012 Oct 17. PMID 22983554, Free PMC Article
    4. A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor. Nie Z, et al. Curr Biol, 2006 Jan 24. PMID 16431365
    5. A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1. Sheridan JM, et al. BMC Cancer, 2015 Apr 3. PMID 25879659, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
      Title: miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
    2. Together these observations suggest that ASAP1 plays a decisive role during the differentiation of mesenchymal progenitor cells
      Title: Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling.
    3. these data indicated that ribosomal protein S19 polymer plays the roles in the early erythroblast differentiation of C57BL/6J mouse spleen
      Title: Erythroblast differentiation at spleen in Q137E mutant ribosomal protein S19 gene knock-in C57BL/6J mice.
    4. results support the hypothesis that ASAP1 is a positive regulator of NM2A.
      Title: The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network.
    5. we demonstrate that Prox1 and Asap1 behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
      Title: A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1.
    6. ASAP1 is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein Arf4 & the 2 G proteins of the Rab family--Rab11 & Rab8--linked by the Rab8 guanine nucleotide exchange factor Rabin8.
      Title: The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting.
    7. ASAP1 was suggested to negatively regulate lipopolysaccharide (LPS)-induced proinflammatory mediators production through down-regulating LPS signaling
      Title: An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide.
    8. ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
      Title: ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
    9. ASAP1 may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain and phosphorylation by Src.
      Title: Src-dependent phosphorylation of ASAP1 regulates podosomes.
    10. DEF-1 alters cell motility through the deactivation of ARF1. In contrast, the inhibition of cell spreading by DEF-1 was not dependent on GAP activity, indicating that spreading and motility are altered by DEF-1 through different pathways.
      Title: DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of dendritic spine development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of membrane tubulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in podosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Names
    130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
    130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
    ADP-ribosylation factor-directed GTPase-activating protein 1
    ARF GTPase-activating protein 1
    PIP2-dependent ARF1 GAP
    development and differentiation-enhancing factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276461.2 → NP_001263390.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC098728, AC131710, AC156573
      Consensus CDS
      CCDS70633.1
      UniProtKB/TrEMBL
      H3BKE6, Q3UJA5
      Related
      ENSMUSP00000135359.2, ENSMUST00000175799.8
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1029 → 1085
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:739 → 1018
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:328 → 434
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:613 → 646
      ANK; ANK repeat [structural motif]
      cd08848
      Location:449 → 570
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:617 → 689
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001276462.2 → NP_001263391.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon, and lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC131710, AC156573
      Consensus CDS
      CCDS70631.1
      UniProtKB/TrEMBL
      E9QN63, H3BL41
      Related
      ENSMUSP00000135643.2, ENSMUST00000177371.8
      Conserved Domains (7) summary
      cd07641
      Location:34 → 248
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1066 → 1122
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:717 → 1055
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:308 → 414
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:593 → 626
      ANK; ANK repeat [structural motif]
      cd08848
      Location:429 → 550
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:597 → 669
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001276463.2 → NP_001263392.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream start codon, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC131710, AC156573
      Consensus CDS
      CCDS70632.1
      UniProtKB/TrEMBL
      E9QMJ1, E9QN63
      Related
      ENSMUSP00000134877.2, ENSMUST00000177083.8
      Conserved Domains (7) summary
      cd07641
      Location:34 → 248
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1054 → 1110
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:705 → 1043
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:296 → 402
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:581 → 614
      ANK; ANK repeat [structural motif]
      cd08848
      Location:417 → 538
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:585 → 657
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_001276467.2 → NP_001263396.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AC098728, AC131710, AC156573
      Consensus CDS
      CCDS70634.1
      UniProtKB/TrEMBL
      E9QMI7
      Related
      ENSMUSP00000135190.2, ENSMUST00000176384.8
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1032 → 1088
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:742 → 1021
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:331 → 437
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:616 → 649
      ANK; ANK repeat [structural motif]
      cd08848
      Location:452 → 573
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:620 → 692
      Ank_2; Ankyrin repeats (3 copies)

    5. NM_001411185.1 → NP_001398114.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC098728, AC131710, AC156573
      Related
      ENSMUSP00000105742.3, ENSMUST00000110115.9

    6. NM_010026.4 → NP_034156.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_034156.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC098728, AC131710, AC156573
      Consensus CDS
      CCDS56986.1
      UniProtKB/Swiss-Prot
      O08612, Q505F0, Q80TG8, Q80UV6, Q99LV8, Q9QWY8, Q9Z2B6
      UniProtKB/TrEMBL
      E9QN63
      Related
      ENSMUSP00000134825.2, ENSMUST00000177374.8
      Conserved Domains (9) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1089 → 1145
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd00204
      Location:616 → 704
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:331 → 437
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:341 → 426
      PH; PH domain
      pfam01412
      Location:454 → 570
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:597 → 682
      Ank_2; Ankyrin repeats (3 copies)
      pfam16638
      Location:931 → 1013
      Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
      sd00045
      Location:616 → 649
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      63958704..64254922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159121.1 → XP_036015014.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

      UniProtKB/TrEMBL
      H3BKD4, Q3UJA5
      Related
      ENSMUSP00000135346.2, ENSMUST00000177035.8
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1017 → 1073
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:727 → 1006
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:316 → 422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:601 → 634
      ANK; ANK repeat [structural motif]
      cd08848
      Location:437 → 558
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:605 → 677
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036159120.1 → XP_036015013.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

      UniProtKB/TrEMBL
      E9QMI7
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1020 → 1076
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:730 → 1009
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:319 → 425
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:604 → 637
      ANK; ANK repeat [structural motif]
      cd08848
      Location:440 → 561
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:608 → 680
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_036159117.1 → XP_036015010.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      E9QN63
      Related
      ENSMUSP00000135718.2, ENSMUST00000175793.8
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1077 → 1133
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:728 → 1066
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:319 → 425
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:604 → 637
      ANK; ANK repeat [structural motif]
      cd08848
      Location:440 → 561
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:608 → 680
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_036159116.1 → XP_036015009.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      E9QN63, H3BJY2
      Related
      ENSMUSP00000135172.2, ENSMUST00000176014.8
      Conserved Domains (7) summary
      cd07641
      Location:54 → 268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1086 → 1142
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:737 → 1075
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:328 → 434
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:613 → 646
      ANK; ANK repeat [structural motif]
      cd08848
      Location:449 → 570
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:617 → 689
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_036159119.1 → XP_036015012.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      E9QN63
      Conserved Domains (7) summary
      cd11965
      Location:1030 → 1086
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:681 → 1019
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:272 → 378
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:557 → 590
      ANK; ANK repeat [structural motif]
      cd08848
      Location:393 → 514
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:561 → 633
      Ank_2; Ankyrin repeats (3 copies)
      cl12013
      Location:1 → 209
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_006520395.2 → XP_006520458.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      E9QN63
      Conserved Domains (7) summary
      cd07641
      Location:138 → 344
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1150 → 1206
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd13251
      Location:392 → 498
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:677 → 710
      ANK; ANK repeat [structural motif]
      cd08848
      Location:513 → 634
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam03154
      Location:830 → 1094
      Atrophin-1; Atrophin-1 family
      pfam12796
      Location:681 → 753
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_006520394.2 → XP_006520457.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      E9QN63
      Conserved Domains (7) summary
      cd07641
      Location:138 → 344
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1153 → 1209
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd13251
      Location:395 → 501
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:680 → 713
      ANK; ANK repeat [structural motif]
      cd08848
      Location:516 → 637
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam03154
      Location:833 → 1097
      Atrophin-1; Atrophin-1 family
      pfam12796
      Location:684 → 756
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_036159115.1 → XP_036015008.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3UJA5
      Conserved Domains (7) summary
      cd11965
      Location:1105 → 1161
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:815 → 1094
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:404 → 510
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:689 → 722
      ANK; ANK repeat [structural motif]
      cd08848
      Location:525 → 646
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:693 → 765
      Ank_2; Ankyrin repeats (3 copies)
      cl12013
      Location:138 → 344
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_006520393.2 → XP_006520456.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E9QN63
      Conserved Domains (7) summary
      cd07641
      Location:138 → 344
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1162 → 1218
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd13251
      Location:404 → 510
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:689 → 722
      ANK; ANK repeat [structural motif]
      cd08848
      Location:525 → 646
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam03154
      Location:842 → 1106
      Atrophin-1; Atrophin-1 family
      pfam12796
      Location:693 → 765
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_006520397.2 → XP_006520460.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E9QMI7
      Conserved Domains (7) summary
      cd11965
      Location:1108 → 1164
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:818 → 1097
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:407 → 513
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:692 → 725
      ANK; ANK repeat [structural motif]
      cd08848
      Location:528 → 649
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:696 → 768
      Ank_2; Ankyrin repeats (3 copies)
      cl12013
      Location:138 → 344
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    11. XM_006520392.2 → XP_006520455.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      E9QN63
      Conserved Domains (7) summary
      cd07641
      Location:138 → 344
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1165 → 1221
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd13251
      Location:407 → 513
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:692 → 725
      ANK; ANK repeat [structural motif]
      cd08848
      Location:528 → 649
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam03154
      Location:845 → 1109
      Atrophin-1; Atrophin-1 family
      pfam12796
      Location:696 → 768
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_036159118.1 → XP_036015011.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      E9QN63
      Conserved Domains (7) summary
      cd07641
      Location:34 → 248
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:1069 → 1125
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:720 → 1058
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:311 → 417
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:596 → 629
      ANK; ANK repeat [structural motif]
      cd08848
      Location:432 → 553
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:600 → 672
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_011245448.1 → XP_011243750.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      E9QN63
      Conserved Domains (7) summary
      cd11965
      Location:1038 → 1094
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      cd13251
      Location:280 → 386
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:565 → 598
      ANK; ANK repeat [structural motif]
      cd08848
      Location:401 → 522
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam03154
      Location:718 → 982
      Atrophin-1; Atrophin-1 family
      pfam12796
      Location:569 → 641
      Ank_2; Ankyrin repeats (3 copies)
      cl12013
      Location:12 → 217
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWY8.2 GenPept UniProtKB/Swiss-Prot:Q9QWY8

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