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    LOC127830080 H3K27ac hESC enhancer GRCh37_chr15:72668147-72668703 [ Homo sapiens (human) ]

    Gene ID: 127830080, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC127830080
    Gene description
    H3K27ac hESC enhancer GRCh37_chr15:72668147-72668703
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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    Genomic context

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    See LOC127830080 in Genome Data Viewer
    Location:
    chromosome: 15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72375806..72376393)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70192610..70193197)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370887 Neighboring gene CUGBP Elav-like family member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:72634699-72635198 Neighboring gene hexosaminidase subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:72667591-72668146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9721 Neighboring gene HEXA antisense RNA 1 Neighboring gene ribosomal protein L12 pseudogene 35 Neighboring gene TMEM202 antisense RNA 1 Neighboring gene transmembrane protein 202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
    2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    General gene information

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    Other Names

    • ATAC-STARR-seq lymphoblastoid active region 9720

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_131562.2 

      Range
      101..688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      72375806..72376393
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      70192610..70193197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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