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    KRBOX5 KRAB box domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 124411, updated on 2-Nov-2024

    Summary

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    Official Symbol
    KRBOX5provided by HGNC
    Official Full Name
    KRAB box domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:26987
    See related
    Ensembl:ENSG00000197302 AllianceGenome:HGNC:26987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF720
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 2.3), brain (RPKM 2.2) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See KRBOX5 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31713244..31761565)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (32100634..32148944)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31724565..31772886)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 22 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31719202-31719702 Neighboring gene clustered mitochondria homolog pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10768 Neighboring gene uncharacterized LOC107983990 Neighboring gene vomeronasal 1 receptor 67 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Lineage-specific transcription factors and the evolution of gene regulatory networks. Nowick K, et al. Brief Funct Genomics, 2010 Jan. PMID 20081217, Free PMC Article
    2. Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes. Hamilton AT, et al. Genome Res, 2006 May. PMID 16606703, Free PMC Article
    3. Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z. Chen Z, et al. J Biol Chem, 2021 Oct. PMID 34537242, Free PMC Article
    4. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 720 (ZNF720) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9313, MGC62019

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    KRAB domain-containing protein 5
    Names
    putative protein ZNF720
    zinc finger protein 720

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130913.2 → NP_001124385.1  KRAB domain-containing protein 5 isoform 9

      See identical proteins and their annotated locations for NP_001124385.1

      Status: VALIDATED

      Source sequence(s)
      AC074050, BC018134
      Consensus CDS
      CCDS45473.1
      UniProtKB/Swiss-Prot
      Q6ZQX1, Q7Z2F6
      Related
      ENSP00000319222.9, ENST00000316491.14
      Conserved Domains (1) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box

    2. NM_001394173.1 → NP_001381102.1  KRAB domain-containing protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:231 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001394174.1 → NP_001381103.1  KRAB domain-containing protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Consensus CDS
      CCDS92144.1
      UniProtKB/TrEMBL
      E9PMU6
      Related
      ENSP00000437310.2, ENST00000529515.2
      Conserved Domains (3) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:229 → 537
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:236 → 256
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001394175.1 → NP_001381104.1  KRAB domain-containing protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (3) summary
      COG5048
      Location:197 → 505
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. NM_001394176.1 → NP_001381105.1  KRAB domain-containing protein 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (2) summary
      COG5048
      Location:175 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001394177.1 → NP_001381106.1  KRAB domain-containing protein 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (2) summary
      COG5048
      Location:163 → 471
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:170 → 190
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001394178.1 → NP_001381107.1  KRAB domain-containing protein 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (2) summary
      COG5048
      Location:163 → 471
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:170 → 190
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001394179.1 → NP_001381108.1  KRAB domain-containing protein 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (2) summary
      COG5048
      Location:163 → 471
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:170 → 190
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001394180.1 → NP_001381109.1  KRAB domain-containing protein 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (2) summary
      COG5048
      Location:163 → 471
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:170 → 190
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001394181.1 → NP_001381110.1  KRAB domain-containing protein 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (1) summary
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    11. NM_001394182.1 → NP_001381111.1  KRAB domain-containing protein 5 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (1) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box

    12. NM_001394183.1 → NP_001381112.1  KRAB domain-containing protein 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (1) summary
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    13. NM_001394184.1 → NP_001381113.1  KRAB domain-containing protein 5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050

    14. NM_001394185.1 → NP_001381114.1  KRAB domain-containing protein 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Conserved Domains (1) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box

    15. NM_001394186.1 → NP_001381115.1  KRAB domain-containing protein 5 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050
      Consensus CDS
      CCDS92145.1
      UniProtKB/TrEMBL
      A0A8I5KY90
      Related
      ENSP00000509660.1, ENST00000689850.1
      Conserved Domains (1) summary
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RNA

    1. NR_172085.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050

    2. NR_172086.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC002519, AC074050

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      31713244..31761565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433621.1 → XP_047289577.1  KRAB domain-containing protein 5 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      32100634..32148944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379609.1 → XP_054235584.1  KRAB domain-containing protein 5 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004300.1: Suppressed sequence

      Description
      NM_001004300.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z2F6.1 GenPept UniProtKB/Swiss-Prot:Q7Z2F6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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