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    ARHGEF7 Rho guanine nucleotide exchange factor 7 [ Leopardus geoffroyi (Geoffroy's cat) ]

    Gene ID: 123599834, updated on 22-Mar-2024

    Summary

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    Gene symbol
    ARHGEF7
    Gene description
    Rho guanine nucleotide exchange factor 7
    See related
    EnsemblRapid:ENSFCTG00000026092
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Leopardus geoffroyi
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Leopardus
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF7 in Genome Data Viewer
    Location:
    chromosome: A1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    100 current O.geoffroyi_Oge1_pat1.0 (GCF_018350155.1) A1 NC_059326.1 (80619863..80755547)

    Chromosome A1 - NC_059326.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 10 Neighboring gene uncharacterized LOC123599829 Neighboring gene sperm acrosome-associated protein 7-like Neighboring gene uncharacterized LOC123599895 Neighboring gene testis expressed 29

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_059326.1 Chromosome A1 Reference O.geoffroyi_Oge1_pat1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Leopardus geoffroyi Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference O.geoffroyi_Oge1_pat1.0 Primary Assembly

    Genomic

    1. NC_059326.1 Reference O.geoffroyi_Oge1_pat1.0 Primary Assembly

      Range
      80619863..80755547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045482189.1 → XP_045338145.1  rho guanine nucleotide exchange factor 7 isoform X2

      Conserved Domains (7) summary
      cd12061
      Location:208 → 261
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      PHA03247
      Location:605 → 688
      PHA03247; large tegument protein UL36; Provisional
      cd00160
      Location:292 → 469
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:500 → 598
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:654 → 752
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:814 → 900
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:158 → 204
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    2. XM_045482296.1 → XP_045338252.1  rho guanine nucleotide exchange factor 7 isoform X13

      Conserved Domains (6) summary
      PTZ00121
      Location:577 → 712
      PTZ00121; MAEBL; Provisional
      cd12061
      Location:95 → 148
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      smart00033
      Location:21 → 96
      CH; Calponin homology domain
      cd00160
      Location:179 → 356
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:387 → 485
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:541 → 639
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    3. XM_045482303.1 → XP_045338259.1  rho guanine nucleotide exchange factor 7 isoform X14

    4. XM_045482270.1 → XP_045338226.1  rho guanine nucleotide exchange factor 7 isoform X10

      Related
      ENSFCTP00000049193.1, ENSFCTT00000071643.1
      Conserved Domains (6) summary
      cd12061
      Location:95 → 148
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:179 → 356
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:387 → 485
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:541 → 639
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:701 → 787
      betaPIX_CC; betaPIX coiled coil
      cl00030
      Location:3 → 89
      CH_SF; calponin homology (CH) domain superfamily

    5. XM_045482199.1 → XP_045338155.1  rho guanine nucleotide exchange factor 7 isoform X3

      Related
      ENSFCTP00000049117.1, ENSFCTT00000071538.1
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:773 → 859
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    6. XM_045482249.1 → XP_045338205.1  rho guanine nucleotide exchange factor 7 isoform X8

      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:714 → 800
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    7. XM_045482279.1 → XP_045338235.1  rho guanine nucleotide exchange factor 7 isoform X11

      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 683
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:684 → 770
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    8. XM_045482260.1 → XP_045338216.1  rho guanine nucleotide exchange factor 7 isoform X9

      Related
      ENSFCTP00000049411.1, ENSFCTT00000071959.1

    9. XM_045482219.1 → XP_045338175.1  rho guanine nucleotide exchange factor 7 isoform X5

      Related
      ENSFCTP00000048795.1, ENSFCTT00000071116.1

    10. XM_045482238.1 → XP_045338194.1  rho guanine nucleotide exchange factor 7 isoform X7

      Related
      ENSFCTP00000048927.1, ENSFCTT00000071284.1

    11. XM_045482288.1 → XP_045338244.1  rho guanine nucleotide exchange factor 7 isoform X12

    12. XM_045482179.1 → XP_045338135.1  rho guanine nucleotide exchange factor 7 isoform X1

      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:616 → 702
      betaPIX_CC; betaPIX coiled coil

    13. XM_045482208.1 → XP_045338164.1  rho guanine nucleotide exchange factor 7 isoform X4

      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:557 → 643
      betaPIX_CC; betaPIX coiled coil

    14. XM_045482334.1 → XP_045338290.1  rho guanine nucleotide exchange factor 7 isoform X1

      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:616 → 702
      betaPIX_CC; betaPIX coiled coil

    15. XM_045482344.1 → XP_045338300.1  rho guanine nucleotide exchange factor 7 isoform X4

      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:557 → 643
      betaPIX_CC; betaPIX coiled coil

    16. XM_045482328.1 → XP_045338284.1  rho guanine nucleotide exchange factor 7 isoform X4

      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:557 → 643
      betaPIX_CC; betaPIX coiled coil

    17. XM_045482321.1 → XP_045338277.1  rho guanine nucleotide exchange factor 7 isoform X1

      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:616 → 702
      betaPIX_CC; betaPIX coiled coil

    18. XM_045482227.1 → XP_045338183.1  rho guanine nucleotide exchange factor 7 isoform X6

      Related
      ENSFCTP00000049496.1, ENSFCTT00000072084.1
      Conserved Domains (7) summary
      cd12061
      Location:85 → 138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169 → 346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377 → 475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:531 → 629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:691 → 777
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:35 → 81
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:1 → 33
      CH_SF; calponin homology (CH) domain superfamily

    19. XM_045482312.1 → XP_045338268.1  rho guanine nucleotide exchange factor 7 isoform X15

    Nucleotide Protein
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