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    CAPN3 calpain 3 [ Varanus komodoensis (Komodo dragon) ]

    Gene ID: 123026806, updated on 22-Mar-2024

    Summary

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    Gene symbol
    CAPN3
    Gene description
    calpain 3
    Locus tag
    EYD10_02567
    See related
    Ensembl:ENSVKKG00000007306
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Varanus komodoensis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus
    Also known as
    Calpain-3
    Orthologs
    human mouse all
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    Genomic context

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    See CAPN3 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    100 current ASM479886v1 (GCF_004798865.1) Unplaced Scaffold NW_025335761.1 (18851396..18881431, complement)

    NW_025335761.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 23 Neighboring gene zinc finger protein 106 Neighboring gene uncharacterized LOC123026812 Neighboring gene glucosidase alpha, neutral C Neighboring gene transmembrane protein 87A Neighboring gene VPS39 subunit of HOPS complex Neighboring gene phospholipase A2 group IVF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_025335761 Unplaced Scaffold Reference ASM479886v1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Varanus komodoensis Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM479886v1

    Genomic

    1. NW_025335761.1 Reference ASM479886v1

      Range
      18851396..18881431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_044436845.1 → XP_044292780.1  calpain-3 isoform X1

      UniProtKB/TrEMBL
      A0A8D2JJM9
      Conserved Domains (3) summary
      smart00230
      Location:55 → 415
      CysPc; Calpain-like thiol protease family
      cd00214
      Location:417 → 574
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16190
      Location:634 → 802
      EFh_PEF_CAPN3; Calcium-activated neutral

    2. XM_044436846.1 → XP_044292781.1  calpain-3 isoform X2

      UniProtKB/TrEMBL
      A0A8D2JJM9
      Conserved Domains (3) summary
      smart00230
      Location:55 → 415
      CysPc; Calpain-like thiol protease family
      cd00214
      Location:417 → 574
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16190
      Location:599 → 767
      EFh_PEF_CAPN3; Calcium-activated neutral

    3. XM_044436847.1 → XP_044292782.1  calpain-3 isoform X3

      Conserved Domains (3) summary
      cd15897
      Location:132 → 160
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:132 → 300
      EFh_PEF; The penta-EF hand (PEF) family
      cl00165
      Location:7 → 72
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

    4. XM_044436848.1 → XP_044292783.1  calpain-3 isoform X4

      UniProtKB/TrEMBL
      A0A8D2J7G7
      Related
      ENSVKKP00000010470.1, ENSVKKT00000010725.1
      Conserved Domains (2) summary
      cd15897
      Location:31 → 60
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:1 → 156
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein
    Heading Accession and Version

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