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    tjp2a tight junction protein 2a (zona occludens 2) [ Carcharodon carcharias (great white shark) ]

    Gene ID: 121277244, updated on 22-Mar-2024

    Summary

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    Gene symbol
    tjp2a
    Gene description
    tight junction protein 2a (zona occludens 2)
    See related
    EnsemblRapid:ENSCHSG00020000287
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Carcharodon carcharias
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Elasmobranchii; Galeomorphii; Galeoidea; Lamniformes; Alopiidae; Carcharodon
    Orthologs
    zebrafish all
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    Genomic context

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    See tjp2a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    100 current sCarCar2.pri (GCF_017639515.1) 4 NC_054470.1 (113995873..114121510, complement)

    Chromosome 4 - NC_054470.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121277383 Neighboring gene beta-crystallin B1-like Neighboring gene family with sequence similarity 189 member A2 Neighboring gene phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like Neighboring gene frataxin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_054470.1 Chromosome 4 Reference sCarCar2.pri Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tight junction protein ZO-2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Carcharodon carcharias Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference sCarCar2.pri Primary Assembly

    Genomic

    1. NC_054470.1 Reference sCarCar2.pri Primary Assembly

      Range
      113995873..114121510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041186452.1 → XP_041042386.1  tight junction protein ZO-2a isoform X4

      Related
      ENSCHSP00020000427.1, ENSCHST00020000575.1
      Conserved Domains (5) summary
      smart00072
      Location:676 → 854
      GuKc; Guanylate kinase homologues
      cd00992
      Location:19 → 101
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:141 → 249
      SF-CC1; splicing factor, CC1-like family
      TIGR02860
      Location:427 → 531
      spore_IV_B; stage IV sporulation protein B
      cl17036
      Location:576 → 642
      SH3; Src Homology 3 domain superfamily

    2. XM_041186451.1 → XP_041042385.1  tight junction protein ZO-2a isoform X3

      Conserved Domains (5) summary
      smart00072
      Location:677 → 855
      GuKc; Guanylate kinase homologues
      cd00992
      Location:20 → 102
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:142 → 250
      SF-CC1; splicing factor, CC1-like family
      TIGR02860
      Location:428 → 532
      spore_IV_B; stage IV sporulation protein B
      cl17036
      Location:577 → 643
      SH3; Src Homology 3 domain superfamily

    3. XM_041186450.1 → XP_041042384.1  tight junction protein ZO-2a isoform X2

      Related
      ENSCHSP00020000324.1, ENSCHST00020000451.1
      Conserved Domains (5) summary
      smart00072
      Location:664 → 842
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:129 → 237
      SF-CC1; splicing factor, CC1-like family
      TIGR02860
      Location:415 → 519
      spore_IV_B; stage IV sporulation protein B
      cl17036
      Location:564 → 630
      SH3; Src Homology 3 domain superfamily

    4. XM_041186449.1 → XP_041042383.1  tight junction protein ZO-2a isoform X1

      Conserved Domains (5) summary
      smart00072
      Location:665 → 843
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:130 → 238
      SF-CC1; splicing factor, CC1-like family
      TIGR02860
      Location:416 → 520
      spore_IV_B; stage IV sporulation protein B
      cl17036
      Location:565 → 631
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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