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    DYSF dysferlin [ Crotalus tigris (Tiger rattlesnake) ]

    Gene ID: 120303900, updated on 21-Mar-2024

    Summary

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    Gene symbol
    DYSF
    Gene description
    dysferlin
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Crotalus tigris
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus
    Orthologs
    human mouse all
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    Genomic context

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    See DYSF in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    100 current ASM1654583v1 (GCF_016545835.1) Unplaced Scaffold NW_024100685.1 (529051..684097)

    NW_024100685.1Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene zinc finger protein 638 Neighboring gene cytochrome P450 26B1 Neighboring gene exocyst complex component 6B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024100685 Unplaced Scaffold Reference ASM1654583v1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-tubule organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monocyte activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in plasma membrane repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dysferlin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Crotalus tigris Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM1654583v1

    Genomic

    1. NW_024100685.1 Reference ASM1654583v1

      Range
      529051..684097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039333809.1 → XP_039189743.1  dysferlin isoform X2

      Conserved Domains (12) summary
      cd04011
      Location:211 → 320
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1146 → 1274
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:374 → 548
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1606 → 1729
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:20 → 124
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1840 → 1971
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:869 → 927
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:780 → 853
      FerB; FerB (NUC096) domain
      pfam08151
      Location:318 → 368
      FerI; FerI (NUC094) domain
      pfam08165
      Location:692 → 749
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1981 → 2092
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1355 → 1425
      C2; C2 domain

    2. XM_039333817.1 → XP_039189751.1  dysferlin isoform X9

      Conserved Domains (12) summary
      cd04011
      Location:211 → 320
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1146 → 1274
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:374 → 548
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1571 → 1694
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:20 → 124
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1805 → 1936
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:869 → 927
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:780 → 853
      FerB; FerB (NUC096) domain
      pfam08151
      Location:318 → 368
      FerI; FerI (NUC094) domain
      pfam08165
      Location:692 → 749
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1946 → 2057
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1341 → 1411
      C2; C2 domain

    3. XM_039333818.1 → XP_039189752.1  dysferlin isoform X10

      Conserved Domains (12) summary
      cd04011
      Location:211 → 320
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1132 → 1260
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:374 → 534
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1557 → 1680
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:20 → 124
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1791 → 1922
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:855 → 913
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:766 → 839
      FerB; FerB (NUC096) domain
      pfam08151
      Location:318 → 368
      FerI; FerI (NUC094) domain
      pfam08165
      Location:678 → 735
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1932 → 2043
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1327 → 1397
      C2; C2 domain

    4. XM_039333812.1 → XP_039189746.1  dysferlin isoform X5

      Conserved Domains (12) summary
      cd04011
      Location:211 → 320
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1146 → 1274
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:374 → 548
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1592 → 1715
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:20 → 124
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1826 → 1957
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:869 → 927
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:780 → 853
      FerB; FerB (NUC096) domain
      pfam08151
      Location:318 → 368
      FerI; FerI (NUC094) domain
      pfam08165
      Location:692 → 749
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1967 → 2078
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1341 → 1411
      C2; C2 domain

    5. XM_039333816.1 → XP_039189750.1  dysferlin isoform X8

      Conserved Domains (12) summary
      cd04011
      Location:211 → 320
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1132 → 1260
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:374 → 534
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1578 → 1701
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:20 → 124
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1812 → 1943
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:855 → 913
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:766 → 839
      FerB; FerB (NUC096) domain
      pfam08151
      Location:318 → 368
      FerI; FerI (NUC094) domain
      pfam08165
      Location:678 → 735
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1953 → 2064
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1327 → 1397
      C2; C2 domain

    6. XM_039333808.1 → XP_039189742.1  dysferlin isoform X1

      Conserved Domains (12) summary
      cd04011
      Location:213 → 322
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1148 → 1276
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:376 → 550
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1608 → 1731
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:21 → 126
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1842 → 1973
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:871 → 929
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:782 → 855
      FerB; FerB (NUC096) domain
      pfam08151
      Location:320 → 370
      FerI; FerI (NUC094) domain
      pfam08165
      Location:694 → 751
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1983 → 2094
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1357 → 1427
      C2; C2 domain

    7. XM_039333813.1 → XP_039189747.1  dysferlin isoform X6

      Conserved Domains (12) summary
      cd04011
      Location:213 → 322
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1148 → 1276
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:376 → 550
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1587 → 1710
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:21 → 126
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1821 → 1952
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:871 → 929
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:782 → 855
      FerB; FerB (NUC096) domain
      pfam08151
      Location:320 → 370
      FerI; FerI (NUC094) domain
      pfam08165
      Location:694 → 751
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1962 → 2073
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1357 → 1427
      C2; C2 domain

    8. XM_039333810.1 → XP_039189744.1  dysferlin isoform X3

      Conserved Domains (12) summary
      cd04011
      Location:213 → 322
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1148 → 1276
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:376 → 550
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1594 → 1717
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:21 → 126
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1828 → 1959
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:871 → 929
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:782 → 855
      FerB; FerB (NUC096) domain
      pfam08151
      Location:320 → 370
      FerI; FerI (NUC094) domain
      pfam08165
      Location:694 → 751
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1969 → 2080
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1343 → 1413
      C2; C2 domain

    9. XM_039333811.1 → XP_039189745.1  dysferlin isoform X4

      Conserved Domains (12) summary
      cd04011
      Location:213 → 322
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1134 → 1262
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:376 → 536
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1594 → 1717
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:21 → 126
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1828 → 1959
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:857 → 915
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:768 → 841
      FerB; FerB (NUC096) domain
      pfam08151
      Location:320 → 370
      FerI; FerI (NUC094) domain
      pfam08165
      Location:680 → 737
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1969 → 2080
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1343 → 1413
      C2; C2 domain

    10. XM_039333814.1 → XP_039189748.1  dysferlin isoform X7

      Conserved Domains (12) summary
      cd04011
      Location:213 → 322
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1134 → 1262
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:376 → 536
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1580 → 1703
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:21 → 126
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1814 → 1945
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      smart00693
      Location:857 → 915
      DysFN; Dysferlin domain, N-terminal region
      pfam08150
      Location:768 → 841
      FerB; FerB (NUC096) domain
      pfam08151
      Location:320 → 370
      FerI; FerI (NUC094) domain
      pfam08165
      Location:680 → 737
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1955 → 2066
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1329 → 1399
      C2; C2 domain

    RNA

    1. XR_005555553.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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