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    CASK calcium/calmodulin dependent serine protein kinase [ Artibeus jamaicensis (Jamaican fruit-eating bat) ]

    Gene ID: 119063839, updated on 30-Mar-2024

    Summary

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    Gene symbol
    CASK
    Gene description
    calcium/calmodulin dependent serine protein kinase
    See related
    EnsemblRapid:ENSAJMG00005014781
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Artibeus jamaicensis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Phyllostomidae; Stenodermatinae; Artibeus
    Orthologs
    human mouse all
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    Genomic context

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    See CASK in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_03 current CSHL_Jam_final (GCF_021234435.1) Unplaced Scaffold NW_026521900.1 (3933281..4423541, complement)

    NW_026521900.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene nyctalopin Neighboring gene proteasome assembly chaperone 2-like Neighboring gene G protein-coupled receptor 34 Neighboring gene G protein-coupled receptor 82 Neighboring gene ubiquitin-40S ribosomal protein S27a-like Neighboring gene 60S ribosomal protein L32-like Neighboring gene bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial-like Neighboring gene uncharacterized LOC119064120 Neighboring gene 60S ribosomal protein L30-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_026521900 Unplaced Scaffold Reference CSHL_Jam_final Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peripheral plasma membrane protein CASK

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_021234435.1-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CSHL_Jam_final Primary Assembly

    Genomic

    1. NW_026521900.1 Reference CSHL_Jam_final Primary Assembly

      Range
      3933281..4423541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_037165398.2 → XP_037021293.1  peripheral plasma membrane protein CASK isoform X1

      Related
      ENSAJMP00005021836.1
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738 → 911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    2. XM_037165406.2 → XP_037021301.1  peripheral plasma membrane protein CASK isoform X2

      Related
      ENSAJMP00005021897.1
      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610 → 671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732 → 905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    3. XM_037165435.2 → XP_037021330.1  peripheral plasma membrane protein CASK isoform X6

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:581 → 642
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:703 → 876
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    4. XM_037165423.2 → XP_037021318.1  peripheral plasma membrane protein CASK isoform X4

      Related
      ENSAJMP00005022068.1
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:593 → 654
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:715 → 888
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    5. XM_037165413.2 → XP_037021308.1  peripheral plasma membrane protein CASK isoform X3

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:604 → 665
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:726 → 899
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    6. XM_037165442.2 → XP_037021337.1  peripheral plasma membrane protein CASK isoform X7

      Related
      ENSAJMP00005022131.1
      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:575 → 636
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:697 → 870
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    7. XM_037165426.2 → XP_037021321.1  peripheral plasma membrane protein CASK isoform X5

      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587 → 648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709 → 882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    8. XM_037165418.2 → XP_037021313.1  peripheral plasma membrane protein CASK isoform X9

      Related
      ENSAJMP00005022015.1
      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:598 → 659
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:720 → 893
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    9. XM_037165446.2 → XP_037021341.1  peripheral plasma membrane protein CASK isoform X8

      Conserved Domains (6) summary
      smart00569
      Location:275 → 328
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:543 → 604
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:415 → 495
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:665 → 838
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:333 → 383
      L27; L27 domain
      cl21453
      Location:1 → 240
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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