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    Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 [ Mus musculus (house mouse) ]

    Gene ID: 117591, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slc2a9provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 9provided by MGI
    Primary source
    MGI:MGI:2152844
    See related
    Ensembl:ENSMUSG00000005107 AllianceGenome:MGI:2152844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glut9; GLUT-9; SLC2A9B; SLC2a9A
    Summary
    Enables D-glucose transmembrane transporter activity and urate transmembrane transporter activity. Involved in urate transport. Acts upstream of or within D-glucose transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including early conceptus; heart; liver; metanephros; and thymus primordium. Used to study abdominal obesity-metabolic syndrome and hyperuricemia. Orthologous to human SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in liver adult (RPKM 6.8), large intestine adult (RPKM 5.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc2a9 in Genome Data Viewer
    Location:
    5 B3; 5 20.43 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38506616..38660488, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38349272..38503147, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26560 Neighboring gene RIKEN cDNA 4930487D11 gene Neighboring gene dopamine receptor D5 Neighboring gene predicted gene, 40290 Neighboring gene STARR-seq mESC enhancer starr_12915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:38871363-38871544 Neighboring gene VISTA enhancer mm253 Neighboring gene predicted gene 15796 Neighboring gene predicted gene, 54329

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse glucose transporter 9 splice variants are expressed in adult liver and kidney and are up-regulated in diabetes. Keembiyehetty C, et al. Mol Endocrinol, 2006 Mar. PMID 16293642
    2. SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney. Auberson M, et al. Pflugers Arch, 2018 Dec. PMID 30105595, Free PMC Article
    3. The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease. Zeng H, et al. Hepatol Int, 2022 Oct. PMID 36006548
    4. GLUT9 is differentially expressed and targeted in the preimplantation embryo. Carayannopoulos MO, et al. Endocrinology, 2004 Mar. PMID 14657010
    5. Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System. Lüscher BP, et al. Cells, 2022 Feb 11. PMID 35203284, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease.
      Title: The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease.
    2. Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.
      Title: Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.
    3. MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells in hyperuricemia.
      Title: MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
    4. these data show that GLUT6 is dispensable for lipopolysaccharide-induced M1 polarization and function
      Title: Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function.
    5. SLC2A9 regulates urate reabsorption in the mouse kidney.
      Title: SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.
    6. Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9).
      Title: Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD.
    7. intestinal uric acid transporter SLC2A9 has a role in early-onset metabolic syndrome in a mouse model
      Title: Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.
    8. Studies confirm the expression of GLUT9a and GLUT9b in murine and human beta-cells.
      Title: Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells.
    9. Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.
      Title: Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.
    10. Characterize in more detail the transport properties of mouse GLUT9 and provide evidence that it functions as a urate uniporter.
      Title: Mouse GLUT9: evidences for a urate uniporter.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hexose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables urate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables urate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fructose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in fructose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monosaccharide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in urate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in urate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 9
    Names
    facilitated glucose transporter, type 9
    glucose transporter type 9
    urate transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012363.2 → NP_001012363.2  solute carrier family 2, facilitated glucose transporter member 9 isoform 2

      See identical proteins and their annotated locations for NP_001012363.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' CDS, compared to variant 1. The encoded protein (isoform 2, also known as the long form of mGLUT9b) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC171271, AK033725, AY776155
      Consensus CDS
      CCDS51484.1
      UniProtKB/TrEMBL
      B9EHN5, Q5ERC7, Q8BZR3
      Related
      ENSMUSP00000066872.6, ENSMUST00000067872.12
      Conserved Domains (1) summary
      cd17432
      Location:25 → 476
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    2. NM_001102414.1 → NP_001095884.1  solute carrier family 2, facilitated glucose transporter member 9 isoform 1

      See identical proteins and their annotated locations for NP_001095884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1, also known as the long form of mGLUT9a).
      Source sequence(s)
      AC171271, AK156740
      Consensus CDS
      CCDS51483.1
      UniProtKB/Swiss-Prot
      A0A0J9YUW8, B7ZNE4, B9EHN5, D3Z1X2, D6REU9, Q3T9X0, Q5ERC7, Q7TSK9, Q7TSP0, Q8BZR3, Q99JJ2
      Related
      ENSMUSP00000063352.6, ENSMUST00000067886.12
      Conserved Domains (1) summary
      cd17432
      Location:40 → 491
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    3. NM_001102415.1 → NP_001095885.1  solute carrier family 2, facilitated glucose transporter member 9 isoform 3

      See identical proteins and their annotated locations for NP_001095885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 3, also known as the short form of mGLUT9a) lacks an internal region and is shorter, compared to isoform 1.
      Source sequence(s)
      AC084071, AC171271, AF490463
      Consensus CDS
      CCDS51482.1
      UniProtKB/TrEMBL
      Q7TSK9
      Related
      ENSMUSP00000118430.2, ENSMUST00000143758.8
      Conserved Domains (2) summary
      cd06174
      Location:42 → 372
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:40 → 388
      Sugar_tr; Sugar (and other) transporter

    4. NM_145559.2 → NP_663534.1  solute carrier family 2, facilitated glucose transporter member 9 isoform 4

      See identical proteins and their annotated locations for NP_663534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and CDS, and lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 4, also known as the short form of mGLUT9b) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084071, BC006076
      Consensus CDS
      CCDS19256.1
      UniProtKB/TrEMBL
      Q99JJ2
      Related
      ENSMUSP00000005238.7, ENSMUST00000005238.13
      Conserved Domains (1) summary
      cl28910
      Location:25 → 369
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      38506616..38660488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503687.5 → XP_006503750.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X2

      See identical proteins and their annotated locations for XP_006503750.1

      UniProtKB/TrEMBL
      Q99JJ2
      Conserved Domains (1) summary
      cl28910
      Location:25 → 369
      MFS; Major Facilitator Superfamily

    2. XM_006503685.5 → XP_006503748.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

      See identical proteins and their annotated locations for XP_006503748.1

      UniProtKB/TrEMBL
      B9EHN5
      Related
      ENSMUSP00000116354.2, ENSMUST00000155634.8
      Conserved Domains (1) summary
      cd17432
      Location:25 → 476
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    3. XM_006503684.5 → XP_006503747.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

      See identical proteins and their annotated locations for XP_006503747.1

      UniProtKB/TrEMBL
      B9EHN5
      Conserved Domains (1) summary
      cd17432
      Location:25 → 476
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    4. XM_011240690.3 → XP_011238992.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

      See identical proteins and their annotated locations for XP_011238992.1

      UniProtKB/TrEMBL
      B9EHN5
      Conserved Domains (1) summary
      cd17432
      Location:25 → 476
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    5. XM_011240689.4 → XP_011238991.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

      See identical proteins and their annotated locations for XP_011238991.1

      UniProtKB/TrEMBL
      B9EHN5
      Conserved Domains (1) summary
      cd17432
      Location:25 → 476
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    6. XM_006503686.5 → XP_006503749.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X2

      See identical proteins and their annotated locations for XP_006503749.1

      UniProtKB/TrEMBL
      Q99JJ2
      Conserved Domains (1) summary
      cl28910
      Location:25 → 369
      MFS; Major Facilitator Superfamily

    7. XM_006503683.5 → XP_006503746.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

      See identical proteins and their annotated locations for XP_006503746.1

      UniProtKB/TrEMBL
      B9EHN5
      Related
      ENSMUSP00000122723.2, ENSMUST00000129099.8
      Conserved Domains (1) summary
      cd17432
      Location:25 → 476
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    8. XM_030254075.2 → XP_030109935.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

      Conserved Domains (1) summary
      cd17432
      Location:25 → 476
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    RNA

    1. XR_004942429.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T9X0.1 GenPept UniProtKB/Swiss-Prot:Q3T9X0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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