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    JAG2 jagged canonical Notch ligand 2 [ Rhinolophus ferrumequinum (greater horseshoe bat) ]

    Gene ID: 117023754, updated on 30-Mar-2024

    Summary

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    Gene symbol
    JAG2
    Gene description
    jagged canonical Notch ligand 2
    See related
    EnsemblRapid:ENSRFEG00010001414
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rhinolophus ferrumequinum
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Rhinolophoidea; Rhinolophidae; Rhinolophinae; Rhinolophus
    Orthologs
    human mouse all
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    Genomic context

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    See JAG2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_02 current mRhiFer1_v1.p (GCF_004115265.2) 6 NC_046289.1 (623240..645925)

    Chromosome 6 - NC_046289.1Genomic Context describing neighboring genes Neighboring gene BRF1 general transcription factor IIIB subunit Neighboring gene BTB domain containing 6 Neighboring gene nudix hydrolase 14 Neighboring gene G protein-coupled receptor 132 Neighboring gene cell division cycle associated 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_046289.1 Chromosome 6 Reference mRhiFer1_v1.p

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein jagged-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_004115265.2-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRhiFer1_v1.p

    Genomic

    1. NC_046289.1 Reference mRhiFer1_v1.p

      Range
      623240..645925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_033108906.1 → XP_032964797.1  protein jagged-2 isoform X4

      UniProtKB/TrEMBL
      A0A671DV14
      Conserved Domains (5) summary
      smart00215
      Location:820 → 891
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:307 → 345
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:351 → 381
      EGF; EGF-like domain
      pfam01414
      Location:178 → 240
      DSL; Delta serrate ligand
      pfam07657
      Location:28 → 103
      MNNL; N-terminus of Notch ligand

    2. XM_033108902.1 → XP_032964793.1  protein jagged-2 isoform X1

      UniProtKB/TrEMBL
      A0A671DMG0, A0A7J7QYD3
      Related
      ENSRFEP00010001993.1, ENSRFET00010002205.2
      Conserved Domains (5) summary
      smart00215
      Location:872 → 943
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:307 → 345
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:351 → 381
      EGF; EGF-like domain
      pfam01414
      Location:178 → 240
      DSL; Delta serrate ligand
      pfam07657
      Location:28 → 103
      MNNL; N-terminus of Notch ligand

    3. XM_033108903.1 → XP_032964794.1  protein jagged-2 isoform X2

      UniProtKB/TrEMBL
      A0A7J7QYD3
      Conserved Domains (5) summary
      smart00215
      Location:871 → 942
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:307 → 345
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:350 → 380
      EGF; EGF-like domain
      pfam01414
      Location:178 → 240
      DSL; Delta serrate ligand
      pfam07657
      Location:28 → 103
      MNNL; N-terminus of Notch ligand

    4. XM_033108904.1 → XP_032964795.1  protein jagged-2 isoform X3

      UniProtKB/TrEMBL
      A0A7J7QYM9
      Related
      ENSRFEP00010002025.2, ENSRFET00010002239.2
      Conserved Domains (5) summary
      smart00215
      Location:834 → 905
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:423 → 458
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:351 → 381
      EGF; EGF-like domain
      pfam01414
      Location:178 → 240
      DSL; Delta serrate ligand
      pfam07657
      Location:28 → 103
      MNNL; N-terminus of Notch ligand
    Nucleotide Protein
    Heading Accession and Version

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