Tpt1 tumor protein, translationally-controlled 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpt1provided by RGD
Official Full Name: tumor protein, translationally-controlled 1provided by RGD
Primary source: RGD:621623
See related: EnsemblRapid:ENSRNOG00000001049 AllianceGenome:RGD:621623
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor binding activity and calcium ion binding activity. Involved in spermatogenesis. Predicted to be located in several cellular components, including microtubule cytoskeleton; multivesicular body; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Spleen (RPKM 8540.3), Muscle (RPKM 8180.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (57562217..57568968)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (51156728..51159629)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (57891680..57894504)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of transcription factor TCTP elevates microRNA-200a expression to restrain Myt1L expression, thereby improving neurobehavior and oxidative stress injury in cerebral palsy rats.
Title: Downregulation of transcription factor TCTP elevates microRNA-200a expression to restrain Myt1L expression, thereby improving neurobehavior and oxidative stress injury in cerebral palsy rats.
TCTP has a pivotal role in cardiomyocyte survival, at least in part through a Bnip3-dependent mechanism.
Title: Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism.
These data suggest an important role for TCTP in regulating the critical vascular cell phenotypes that have been implicated in the pathobiology of Pulmonary arterial hypertension.
Title: A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.
Tumor protein translationally-controlled -induced dopamine release from neuronal PC12 cells was modulated by a Ca(2+)-independent mechanism that involved PLA in the process, suggesting the regulatory role of TCTP in the neuronal functions.
Title: Translationally Controlled Tumor Protein Stimulates Dopamine Release from PC12 Cells via Ca(2+)-Independent Phospholipase A₂ Pathways.
After acute spinal cord injury, TCTP in astrocytes gradually increased, peaking at day 3 and returning to basal levels by day 14. TCTP knockdown reduced astrocyte migration and proliferation.
Title: TCTP Expression After Rat Spinal Cord Injury: Implications for Astrocyte Proliferation and Migration.

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General gene information

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Markers

PMC134017P1 (e-PCR)
- UniSTS:270716

RH141654 (e-PCR)
- UniSTS:223647

MARC_2026-2027:991932441:1 (e-PCR)
- UniSTS:230899

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of ectoderm development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ectoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: translationally-controlled tumor protein

Names: TCTP; lens epithelial protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053867.2 → NP_446319.1 translationally-controlled tumor protein

See identical proteins and their annotated locations for NP_446319.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P63029

UniProtKB/TrEMBL

A0A8I5ZVT0, A6HTT6

Related

ENSRNOP00000001383.4, ENSRNOT00000001383.9

Conserved Domains (1) summary

pfam00838
Location:1 → 167

TCTP; Translationally controlled tumor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

57562217..57568968

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273910.1 → XP_063129980.1 translationally-controlled tumor protein isoform X2

UniProtKB/Swiss-Prot

P63029

UniProtKB/TrEMBL

A6HTT6
XM_063273909.1 → XP_063129979.1 translationally-controlled tumor protein isoform X2

UniProtKB/Swiss-Prot

P63029

UniProtKB/TrEMBL

A6HTT6
XM_063273908.1 → XP_063129978.1 translationally-controlled tumor protein isoform X1
XM_063273911.1 → XP_063129981.1 translationally-controlled tumor protein isoform X3