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    capn3.S calpain 3 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 108700461, updated on 4-Nov-2024

    Summary

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    Official Symbol
    capn3.S
    Official Full Name
    calpain 3 S homeolog
    Primary source
    Xenbase:XB-GENE-17345671
    Locus tag
    XELAEV_18041044mg
    See related
    EnsemblRapid:ENSXLAG00005023003 AllianceGenome:Xenbase:XB-GENE-17345671
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    canp3; lgmd2; ncl-1; canpl3; lgmd2a
    Summary
    Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Orthologous to human CAPN3 (calpain 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See capn3.S in Genome Data Viewer
    Location:
    chromosome: 8S
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (3077876..3131164, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (3066805..3120213, complement)

    Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene cofilin 2 (non-muscle) S homeolog Neighboring gene sorting nexin 6 S homeolog Neighboring gene C-type lectin domain family 14 member A S homeolog Neighboring gene somatostatin receptor 1 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    calpain-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      3077876..3131164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041574841.1 → XP_041430775.1  calpain-3 isoform X5

      UniProtKB/TrEMBL
      A0A8J1LPZ4, A0A974H534
      Related
      ENSXLAP00005067981.1, ENSXLAT00005069515.1
      Conserved Domains (3) summary
      smart00230
      Location:53 → 369
      CysPc; Calpain-like thiol protease family
      cd00214
      Location:373 → 528
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16190
      Location:552 → 720
      EFh_PEF_CAPN3; Calcium-activated neutral

    2. XM_041574840.1 → XP_041430774.1  calpain-3 isoform X4

      UniProtKB/TrEMBL
      A0A8J1LNK8, A0A974H8K8
      Conserved Domains (3) summary
      smart00230
      Location:53 → 369
      CysPc; Calpain-like thiol protease family
      cd00214
      Location:373 → 528
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16190
      Location:594 → 762
      EFh_PEF_CAPN3; Calcium-activated neutral

    3. XM_041574839.1 → XP_041430773.1  calpain-3 isoform X3

      UniProtKB/TrEMBL
      A0A8J1LMG9, A0A974H534
      Conserved Domains (3) summary
      smart00230
      Location:53 → 412
      CysPc; Calpain-like thiol protease family
      cd00214
      Location:416 → 571
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16190
      Location:595 → 763
      EFh_PEF_CAPN3; Calcium-activated neutral

    4. XM_041574838.1 → XP_041430772.1  calpain-3 isoform X2

      UniProtKB/TrEMBL
      A0A8J1LMM2, A0A974H534
      Conserved Domains (3) summary
      smart00230
      Location:53 → 412
      CysPc; Calpain-like thiol protease family
      cd00214
      Location:416 → 571
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16190
      Location:602 → 770
      EFh_PEF_CAPN3; Calcium-activated neutral

    5. XM_041574837.1 → XP_041430771.1  calpain-3 isoform X1

      UniProtKB/TrEMBL
      A0A8J1LNM5, A0A974H8K8
      Related
      ENSXLAP00005068013.1, ENSXLAT00005069547.1
      Conserved Domains (3) summary
      smart00230
      Location:53 → 412
      CysPc; Calpain-like thiol protease family
      cd00214
      Location:416 → 571
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16190
      Location:637 → 805
      EFh_PEF_CAPN3; Calcium-activated neutral

    6. XM_041574842.1 → XP_041430776.1  calpain-3 isoform X6

      UniProtKB/TrEMBL
      A0A8J1LNN1
      Conserved Domains (2) summary
      cd15897
      Location:31 → 60
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:1 → 156
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein Strain
    Heading Accession and Version

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