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    Ubxn8 UBX domain protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 108159, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ubxn8provided by MGI
    Official Full Name
    UBX domain protein 8provided by MGI
    Primary source
    MGI:MGI:1337129
    See related
    Ensembl:ENSMUSG00000052906 AllianceGenome:MGI:1337129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rep-8; Rep8h; Ubxd6; D0H8S2298E
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in endoplasmic reticulum membrane; nucleolus; and nucleoplasm. Predicted to be active in endoplasmic reticulum and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human UBXN8 (UBX domain protein 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 11.6), placenta adult (RPKM 3.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubxn8 in Genome Data Viewer
    Location:
    8 A4; 8 20.65 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34109614..34135515, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33619586..33645476, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 1, related sequence 17 Neighboring gene STARR-seq mESC enhancer starr_21108 Neighboring gene testis expressed gene 15 meiosis and synapsis associated Neighboring gene STARR-seq mESC enhancer starr_21109 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Neighboring gene STARR-positive B cell enhancer ABC_E4996 Neighboring gene STARR-seq mESC enhancer starr_21112 Neighboring gene predicted gene, 33433 Neighboring gene glutathione reductase Neighboring gene predicted gene, 24727

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structures of mouse Rep-8 cDNA and genomic clones. Yamabe Y, et al. Gene, 1999 Feb 4. PMID 9931425
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBX domain-containing protein 8
    Names
    UBX domain containing 6
    UBX domain-containing protein 6
    protein Rep-8
    reproduction 8 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178648.2 → NP_848763.2  UBX domain-containing protein 8

      See identical proteins and their annotated locations for NP_848763.2

      Status: VALIDATED

      Source sequence(s)
      AK132565, AK161397, BY613198
      Consensus CDS
      CCDS22234.1
      UniProtKB/Swiss-Prot
      Q9QZ49
      UniProtKB/TrEMBL
      Q3TTF2
      Related
      ENSMUSP00000092992.5, ENSMUST00000095349.6
      Conserved Domains (1) summary
      cl00155
      Location:192 → 271
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      34109614..34135515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508980.5 → XP_006509043.1  UBX domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ49
      Conserved Domains (2) summary
      cd01774
      Location:150 → 225
      UBX_UBXN8; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins
      pfam09751
      Location:67 → 171
      Es2; Nuclear protein Es2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZ49.1 GenPept UniProtKB/Swiss-Prot:Q9QZ49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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