LOC107982234 WT1/WT1-AS bi-directional promoter region [Homo sapiens (human)] - Gene

Summary

Gene symbol: LOC107982234
Gene description: WT1/WT1-AS bi-directional promoter region
Gene type: biological region
Feature type(s): misc_structure
protein_bind
regulatory: DNase_I_hypersensitive_site, TATA_box, enhancer, promoter, silencer, transcriptional_cis_regulatory_region
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This genomic region encompasses regulatory elements in the 5' region of the Wilms tumor 1 (WT1) gene, including promoters and enhancers of WT1, as well as promoters for the WT1 antisense RNA (WT1-AS) gene. Wt1 protein autoregulates this region by increasing transcription from the WT1-AS gene and suppressing transcription from the WT1 promoter. The WT1-AS RNA may also bind to this region and downregulate WT1 transcription. Expression of WT1 is positively regulated through binding of paired box proteins and ETS variant 4. Both the WT1 and WT1-AS promoter undergo parent-of-origin specific imprinting, and the WT1 promoter is often methylated and silenced in tumor cells. Methylation-dependent repression may be blocked by binding of CCCTC-binding factor. Two subregions were shown to be active enhancers by ChIP-STARR-seq in naive human embryonic stem cells, where both are marked by the K3K4me1 histone modification and one is additionally marked by H3K27ac. [provided by RefSeq, Nov 2022]
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (32430169..32437423)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (32565658..32572908)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (32451715..32458969)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32451715-32452434
H3K4me1 hESC enhancer GRCh37_chr11:32455434-32456018
WT1 5' proximal regulatory region

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.