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    Lrrtm2 leucine rich repeat transmembrane neuronal 2 [ Mus musculus (house mouse) ]

    Gene ID: 107065, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lrrtm2provided by MGI
    Official Full Name
    leucine rich repeat transmembrane neuronal 2provided by MGI
    Primary source
    MGI:MGI:2389174
    See related
    Ensembl:ENSMUSG00000071862 AllianceGenome:MGI:2389174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0416; C630011A14Rik
    Summary
    Predicted to enable neurexin family protein binding activity. Acts upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Predicted to be located in excitatory synapse and membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Is expressed in neural tube and neural tube lateral wall. Orthologous to human LRRTM2 (leucine rich repeat transmembrane neuronal 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 3.7), frontal lobe adult (RPKM 3.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrtm2 in Genome Data Viewer
    Location:
    18 B1; 18 18.94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35342056..35348077, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35209003..35215024, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3587 Neighboring gene predicted gene, 46617 Neighboring gene catenin alpha 1 Neighboring gene STARR-seq mESC enhancer starr_44229 Neighboring gene STARR-positive B cell enhancer ABC_E10985 Neighboring gene STARR-seq mESC enhancer starr_44230 Neighboring gene SIL1 nucleotide exchange factor Neighboring gene predicted gene, 57657 Neighboring gene STARR-seq mESC enhancer starr_44231 Neighboring gene predicted gene, 57820

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits. Dhume SH, et al. Elife, 2022 Jun 6. PMID 35662394, Free PMC Article
    2. Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. Bhouri M, et al. Proc Natl Acad Sci U S A, 2018 Jun 5. PMID 29784826, Free PMC Article
    3. Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin. Chamma I, et al. Nat Commun, 2016 Mar 16. PMID 26979420, Free PMC Article
    4. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Paatero A, et al. Biochemistry, 2016 Feb 16. PMID 26785044
    5. Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2. Hayer SN, et al. J Biol Chem, 2015 Feb 27. PMID 25527504, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.
      Title: Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.
    2. The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated interactions and overlaps with the Nrxn-neuroligin interface.
      Title: Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
    3. Genetic deletion of LRRTM1,2 in vivo in CA1 neurons using Cre recombinase-expressing lentiviruses dramatically impaired long-term potentiation (LTP), an impairment that was rescued by simultaneous expression of LRRTM2, but not LRRTM4.
      Title: Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons.
    4. The crystal structure of a thermostabilized LRRTM2 protein was determined.
      Title: Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding.
    5. Data indicate that neural Cell Adhesion Molecules Lrrtm1 and Lrrtm2 mRNA expression is controlled by synaptic activity and nuclear calcium signaling.
      Title: Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2.
    6. This study demonistrated that LRRTM2 is essential for maintenance of long-term potentiation in mice hippocampus.
      Title: Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation.
    7. The LRRTM2 acts redundantly to maintain excitatory synapses and that synapse elimination caused by the absence of LRRTM2 is promoted by synaptic activity and mediated by a postsynaptic Ca(2+)/CaM-dependent signaling pathway.
      Title: Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neurexin family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurexin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of receptor internalization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synapse organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat transmembrane neuronal protein 2
    Names
    leucine-rich repeat transmembrane neuronal 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178005.4 → NP_821072.1  leucine-rich repeat transmembrane neuronal protein 2 precursor

      See identical proteins and their annotated locations for NP_821072.1

      Status: VALIDATED

      Source sequence(s)
      AC121874, AK046774
      Consensus CDS
      CCDS50251.1
      UniProtKB/Swiss-Prot
      Q80U08, Q8BGA3
      UniProtKB/TrEMBL
      Q8C8L1
      Related
      ENSMUSP00000089225.4, ENSMUST00000091636.5
      Conserved Domains (3) summary
      TIGR00864
      Location:284 → 351
      PCC; polycystin cation channel protein
      COG4886
      Location:65 → 312
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:66 → 86
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35342056..35348077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGA3.1 GenPept UniProtKB/Swiss-Prot:Q8BGA3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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