U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial [ Homo sapiens (human) ]

    Gene ID: 10667, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FARS2provided by HGNC
    Official Full Name
    phenylalanyl-tRNA synthetase 2, mitochondrialprovided by HGNC
    Primary source
    HGNC:HGNC:21062
    See related
    Ensembl:ENSG00000145982 MIM:611592; AllianceGenome:HGNC:21062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FARS1; PheRS; SPG77; COXPD14; HSPC320; mtPheRS
    Summary
    This gene encodes a protein that transfers phenylalanine to its cognate tRNA. This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.7), testis (RPKM 1.6) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FARS2 in Genome Data Viewer
    Location:
    6p25.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (5249934..5771583)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (5119147..5640982)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (5261240..5771816)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LYRM4 antisense RNA 1 Neighboring gene LYR motif containing 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:5193017-5193524 Neighboring gene microRNA 3691 Neighboring gene Sharpr-MPRA regulatory region 15549 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:5230418-5231617 Neighboring gene uncharacterized LOC124901249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23904 Neighboring gene Sharpr-MPRA regulatory region 4425 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:5368745-5369944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23906 Neighboring gene NANOG hESC enhancer GRCh37_chr6:5412113-5412622 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:5438556-5439472 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:5439473-5440389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:5456946-5457932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23907 Neighboring gene FARS2 antisense RNA 1 Neighboring gene MPRA-validated peak5636 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23908 Neighboring gene NANOG hESC enhancer GRCh37_chr6:5529614-5530223 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:5541695-5542894 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:5581546-5582745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23910 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 37 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:5639236-5640099 Neighboring gene uncharacterized LOC101927950 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:5665450-5666649 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:5672975-5673971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:5737751-5738252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:5783313-5783996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:5783997-5784680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:5804076-5804576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:5804577-5805077 Neighboring gene uncharacterized LOC124901250 Neighboring gene ribosomal protein L34 pseudogene 16

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine. Klipcan L, et al. Proc Natl Acad Sci U S A, 2009 Jul 7. PMID 19549855, Free PMC Article
    2. Mitochondrial aminoacyl-tRNA synthetase single-nucleotide polymorphisms that lead to defects in refolding but not aminoacylation. Banerjee R, et al. J Mol Biol, 2011 Jul 8. PMID 21601574
    3. Mitochondrial phenylalanyl-tRNA synthetase mutations underlie fatal infantile Alpers encephalopathy. Elo JM, et al. Hum Mol Genet, 2012 Oct 15. PMID 22833457
    4. Mutations in FARS2 and non-fatal mitochondrial dysfunction in two siblings. Vernon HJ, et al. Am J Med Genet A, 2015 May. PMID 25851414
    5. Large-scale movement of functional domains facilitates aminoacylation by human mitochondrial phenylalanyl-tRNA synthetase. Yadavalli SS, et al. FEBS Lett, 2009 Oct 6. PMID 19737557

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System.
      Title: FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System.
    2. Two Chinese siblings of combined oxidative phosphorylation deficiency 14 caused by compound heterozygous variants in FARS2.
      Title: Two Chinese siblings of combined oxidative phosphorylation deficiency 14 caused by compound heterozygous variants in FARS2.
    3. Novel FARS2 variants in patients with early onset encephalopathy with or without epilepsy associated with long survival.
      Title: Novel FARS2 variants in patients with early onset encephalopathy with or without epilepsy associated with long survival.
    4. Phenotypic diversity of brain MRI patterns in mitochondrial aminoacyl-tRNA synthetase mutations.
      Title: Phenotypic diversity of brain MRI patterns in mitochondrial aminoacyl-tRNA synthetase mutations.
    5. Breaking a single hydrogen bond in the mitochondrial tRNA(Phe) -PheRS complex leads to phenotypic pleiotropy of human disease.
      Title: Breaking a single hydrogen bond in the mitochondrial tRNA(Phe) -PheRS complex leads to phenotypic pleiotropy of human disease.
    6. the presence of aggregation-prone insoluble human mitochondrial phenylalanyl-tRNA synthetase (HsmitPheRS) variants could have a detrimental impact on organellar translation, and potentially impact normal mitochondrial function in Alpers encephalopathy
      Title: Biophysical characterization Of Alpers encephalopathy associated mutants of human mitochondrial phenylalanyl-tRNA synthetase.
    7. The total number of unique pathogenic FARS2 variants known to date is 21 including three different partial gene deletions reported in four individuals. Except for the large deletions, all variants but two (one in-frame deletion of one amino acid and one splice-site variant) are missense. All large deletions and the single splice-site variant are in trans with a missense variant.
      Title: FARS2 deficiency; new cases, review of clinical, biochemical, and molecular spectra, and variants interpretation based on structural, functional, and evolutionary significance.
    8. Based on the phenotypic data of previously reported subjects and the two subjects reported here, we conclude that FARS2 deficiency can be associated with two phenotypes: (i) an epileptic phenotype, and (ii) a spastic paraplegia phenotype.
      Title: New insights into the phenotype of FARS2 deficiency.
    9. in patients with drug-resistant infantile spasm syndrome, associated with focal seizures, mild metabolic changes, and cerebral atrophy with volume loss of white matter on MRI, mutations in FARS2 should be considered.
      Title: Clinical findings in a patient with FARS2 mutations and early-infantile-encephalopathy with epilepsy.
    10. Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2 have been described.
      Title: Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Combined oxidative phosphorylation defect type 14
    MedGen: C4755312 OMIM: 614946 GeneReviews: FARS2 Deficiency
    		not available
    Hereditary spastic paraplegia 77
    MedGen: C5569007 OMIM: 617046 GeneReviews: FARS2 Deficiency
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
    EBI GWAS Catalog
    Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phenylalanine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation TAS
    Traceable Author Statement
    more info
    		  
    involved_in tRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phenylalanine--tRNA ligase, mitochondrial
    Names
    dJ236A3.1 (phenylalanine-tRNA synthetase)
    dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))
    mitochondrial PHERS
    phenylalanine tRNA ligase 2, mitochondrial
    phenylalanine translase
    phenylalanine-tRNA synthetase 1 (mitochondrial)
    NP_001305801.1
    NP_001361804.1
    NP_001361805.1
    NP_001361806.1
    NP_001361807.1
    NP_001361808.1
    NP_001362186.1
    NP_001362187.1
    NP_001362188.1
    NP_001362189.1
    NP_006558.1
    XP_006715029.1
    XP_011512549.1
    XP_011512550.1
    XP_011512551.1
    XP_011512553.1
    XP_047274042.1
    XP_047274043.1
    XP_054210022.1
    XP_054210023.1
    XP_054210024.1
    XP_054210025.1
    XP_054210026.1
    XP_054210027.1
    XP_054210028.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033003.3 RefSeqGene

      Range
      16581..526651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318872.2 → NP_001305801.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Consensus CDS
      CCDS4494.1
      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Related
      ENSP00000316335.5, ENST00000324331.10
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase

    2. NM_001374875.1 → NP_001361804.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Consensus CDS
      CCDS4494.1
      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase

    3. NM_001374876.1 → NP_001361805.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Consensus CDS
      CCDS4494.1
      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase

    4. NM_001374877.1 → NP_001361806.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Consensus CDS
      CCDS4494.1
      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase

    5. NM_001374878.1 → NP_001361807.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Consensus CDS
      CCDS4494.1
      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase

    6. NM_001374879.1 → NP_001361808.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Consensus CDS
      CCDS4494.1
      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase

    7. NM_001375257.1 → NP_001362186.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Consensus CDS
      CCDS4494.1
      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase

    8. NM_001375258.1 → NP_001362187.1  phenylalanine--tRNA ligase, mitochondrial isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 406
      PLN02788; phenylalanine-tRNA synthetase

    9. NM_001375259.1 → NP_001362188.1  phenylalanine--tRNA ligase, mitochondrial isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Conserved Domains (1) summary
      PLN02788
      Location:1 → 218
      PLN02788; phenylalanine-tRNA synthetase

    10. NM_001375260.1 → NP_001362189.1  phenylalanine--tRNA ligase, mitochondrial isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL022097, AL121978, AL133473, AL392184, AL590868
      Conserved Domains (1) summary
      PLN02788
      Location:1 → 218
      PLN02788; phenylalanine-tRNA synthetase

    11. NM_006567.5 → NP_006558.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_006558.1

      Status: REVIEWED

      Source sequence(s)
      AF097441, BC020239, CA432122, DA516347
      Consensus CDS
      CCDS4494.1
      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062
      UniProtKB/TrEMBL
      A0A3B3ITR6
      Related
      ENSP00000274680.4, ENST00000274680.9
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      5249934..5771583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418086.1 → XP_047274042.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062

    2. XM_047418087.1 → XP_047274043.1  phenylalanine--tRNA ligase, mitochondrial isoform X6

    3. XM_011514248.4 → XP_011512550.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A3B3ITR6
      Related
      ENSP00000497889.1, ENST00000648580.1
      Conserved Domains (2) summary
      smart00896
      Location:358 → 408
      FDX-ACB; Ferredoxin-fold anticodon binding domain
      cd00496
      Location:84 → 338
      PheRS_alpha_core; Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible ...

    4. XM_011514249.3 → XP_011512551.1  phenylalanine--tRNA ligase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (2) summary
      smart00896
      Location:358 → 404
      FDX-ACB; Ferredoxin-fold anticodon binding domain
      cd00496
      Location:84 → 338
      PheRS_alpha_core; Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible ...

    5. XM_011514247.4 → XP_011512549.1  phenylalanine--tRNA ligase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITR6
      Conserved Domains (2) summary
      smart00896
      Location:358 → 404
      FDX-ACB; Ferredoxin-fold anticodon binding domain
      cd00496
      Location:84 → 338
      PheRS_alpha_core; Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible ...

    6. XM_011514251.4 → XP_011512553.1  phenylalanine--tRNA ligase, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl00268
      Location:84 → 302
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    7. XM_006714966.4 → XP_006715029.1  phenylalanine--tRNA ligase, mitochondrial isoform X6

      Conserved Domains (1) summary
      cl00268
      Location:84 → 303
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    RNA

    1. XR_007059197.1 RNA Sequence

    2. XR_007059196.1 RNA Sequence

    3. XR_926027.4 RNA Sequence

    4. XR_007059198.1 RNA Sequence

    5. XR_007059199.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      5119147..5640982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354047.1 → XP_054210022.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B2R664, O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062

    2. XM_054354053.1 → XP_054210028.1  phenylalanine--tRNA ligase, mitochondrial isoform X6

    3. XM_054354049.1 → XP_054210024.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

    4. XM_054354050.1 → XP_054210025.1  phenylalanine--tRNA ligase, mitochondrial isoform X4

    5. XM_054354048.1 → XP_054210023.1  phenylalanine--tRNA ligase, mitochondrial isoform X2

    6. XM_054354051.1 → XP_054210026.1  phenylalanine--tRNA ligase, mitochondrial isoform X5

    7. XM_054354052.1 → XP_054210027.1  phenylalanine--tRNA ligase, mitochondrial isoform X6

    RNA

    1. XR_008487238.1 RNA Sequence

    2. XR_008487237.1 RNA Sequence

    3. XR_008487239.1 RNA Sequence

    4. XR_008487236.1 RNA Sequence

    5. XR_008487240.1 RNA Sequence

    6. XR_008487241.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95363.1 GenPept UniProtKB/Swiss-Prot:O95363

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous